4UYF
N-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1184 |
| Chain | Residue |
| A | ASN146 |
| A | THR150 |
| A | TYR153 |
| A | GLU170 |
| B | ASN146 |
| B | THR150 |
| B | TYR153 |
| B | GLU170 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1190 |
| Chain | Residue |
| A | GLN167 |
| A | GLU170 |
| A | HOH2149 |
| A | HOH2169 |
| B | ASN146 |
| B | THR150 |
| A | TYR153 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO C 1182 |
| Chain | Residue |
| C | MET165 |
| C | HOH2012 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 73B A 1191 |
| Chain | Residue |
| A | TRP97 |
| A | PRO98 |
| A | PHE99 |
| A | LYS107 |
| A | LEU108 |
| A | ASN156 |
| A | HOH2080 |
| A | HOH2170 |
| A | HOH2171 |
| A | HOH2172 |
| B | GLN94 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 73B B 1185 |
| Chain | Residue |
| A | GLN94 |
| B | TRP97 |
| B | PRO98 |
| B | PHE99 |
| B | LEU110 |
| B | ASN156 |
| B | HOH2044 |
| B | HOH2110 |
| B | HOH2111 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 73B C 1183 |
| Chain | Residue |
| A | ASN77 |
| A | GLN80 |
| A | HIS83 |
| A | LYS84 |
| A | PRO181 |
| A | HOH2012 |
| A | HOH2018 |
| A | HOH2020 |
| C | TRP97 |
| C | PRO98 |
| C | LEU110 |
| C | ASN156 |
| C | HOH2039 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1186 |
| Chain | Residue |
| B | ARG100 |
| B | HOH2009 |
| B | HOH2012 |
| B | HOH2014 |
| B | HOH2113 |
| C | ARG128 |
| C | ASN132 |
| C | TYR134 |
| C | HOH2062 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1192 |
| Chain | Residue |
| A | LYS84 |
| A | LYS88 |
| A | HOH2019 |
| C | ARG100 |
| C | GLN101 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1184 |
| Chain | Residue |
| C | HIS83 |
| C | MET87 |
| C | LYS88 |
| C | TRP91 |
| C | LYS127 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 | |
| B | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
