4UXU

Crystal Structure of the Extracellular Domain of the Human Alpha9 Nicotinic Acetylcholine Receptor In Complex with Methyllycaconitine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9	polymer	218	25307.0	2	UniProt (Q9UGM1) Pfam (PF02931) In PDB	HOMO SAPIENS (HUMAN)	NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9, NACHR ALP HA-9, HUMAN ALPHA9 NICOTINIC ACETYLCHOLINE RECEPTOR
2	A, B	METHYLLYCACONITINE	non-polymer		682.8	2	Chemie (MLK)
3	A, B	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	4	Chemie (EPE)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	A, B	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7		water	water		18.0	502	Chemie (HOH)

Sequence modifications

A, B: 1 - 212 (UniProt: Q9UGM1)

PDB	External Database	Details
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50614.1
Non-Polymers*	Number of molecules	15
	Total formula weight	3435.8
All*	Total formula weight	54049.9

*Water molecules are not included.