4UXU
Crystal Structure of the Extracellular Domain of the Human Alpha9 Nicotinic Acetylcholine Receptor In Complex with Methyllycaconitine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045211 | cellular_component | postsynaptic membrane |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045211 | cellular_component | postsynaptic membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CvVdVtyFPfDnqqC |
| Chain | Residue | Details |
| A | CYS130-CYS144 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 422 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA1-SER212 | |
| B | ALA1-SER212 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Key residue important for potent inhibition of the CHRNA9-CHRNA10 receptor by the alpha-conotoxin RgIA (AC P0C1D0) => ECO:0000250|UniProtKB:P43144 |
| Chain | Residue | Details |
| A | ASP121 | |
| B | ASP121 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN32 | |
| A | ASN145 | |
| B | ASN32 | |
| B | ASN145 |
