4UX8
RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | polymer | 607 | 67922.5 | 2 | UniProt (P07949) Pfam (PF17756) Pfam (PF00028) Pfam (PF17812) Pfam (PF17813) Pfam (PF22540) | HOMO SAPIENS (HUMAN) | CADHERIN FAMILY MEMBER 12, PROTO-ONCOGENE C-RET, RET RECEPTOR TYROSINE KINASE |
| 2 | C, E (C, E) | GDNF FAMILY RECEPTOR ALPHA-1 | polymer | 463 | 51091.3 | 2 | UniProt (O35748) Pfam (PF02351) UniProt (by SIFTS) (Q62997) | RATTUS NORVEGICUS (NORWAY RAT) | GFR ALPHA 1 |
| 3 | D, F (D, F) | GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR | polymer | 134 | 15096.2 | 2 | UniProt (P39905) Pfam (PF00019) | HOMO SAPIENS (HUMAN) | HGDNF, ASTROCYTE-DERIVED TROPHIC FACTOR, ATF, GDNF |
| 4 | G, H (G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | I, J, K, L, M... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) |
Sequence modifications
A, B: 29 - 635 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Arg 87 | Cys 87 | engineered mutation |
| Gln 98 | Asn 98 | conflict |
| Gln 199 | Asn 199 | conflict |
| Ser 216 | Cys 216 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 268220.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 240.5 | |
| All* | Total formula weight | 269309.4 |
