4UX8
RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0007156 | biological_process | homophilic cell adhesion via plasma membrane adhesion molecules |
| A | 0016020 | cellular_component | membrane |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0007156 | biological_process | homophilic cell adhesion via plasma membrane adhesion molecules |
| B | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0008083 | molecular_function | growth factor activity |
| D | 0030116 | molecular_function | glial cell-derived neurotrophic factor receptor binding |
| D | 0030971 | molecular_function | receptor tyrosine kinase binding |
| E | 0038023 | molecular_function | signaling receptor activity |
| F | 0008083 | molecular_function | growth factor activity |
| F | 0030116 | molecular_function | glial cell-derived neurotrophic factor receptor binding |
| F | 0030971 | molecular_function | receptor tyrosine kinase binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | LIPID: GPI-anchor amidated serine => ECO:0000255 |
| Chain | Residue | Details |
| C | LYS435 | |
| E | LYS435 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN40 | |
| B | ASP230 | |
| B | ASP264 | |
| B | GLU265 | |
| B | ASP266 | |
| B | SER268 | |
| B | ASP300 | |
| B | ASP302 | |
| C | THR352 | |
| C | THR411 | |
| E | ASN40 | |
| E | THR352 | |
| E | THR411 | |
| A | ASP300 | |
| A | ASP302 | |
| B | GLU178 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31535977, ECO:0007744|PDB:6Q2J |
| Chain | Residue | Details |
| A | ASN179 | |
| A | ASP584 | |
| B | ASN179 | |
| B | GLU232 | |
| B | ASP267 | |
| B | ASP378 | |
| B | THR564 | |
| B | CYS565 | |
| B | ASP567 | |
| B | HIS569 | |
| B | GLU574 | |
| A | GLU232 | |
| B | ASP584 | |
| A | ASP267 | |
| A | ASP378 | |
| A | THR564 | |
| A | CYS565 | |
| A | ASP567 | |
| A | HIS569 | |
| A | GLU574 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Breakpoint for translocation to form the TRIM27/RET oncogene => ECO:0000269|PubMed:3037315 |
| Chain | Residue | Details |
| A | ARG587 | |
| B | ARG587 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN98 | |
| A | ASN468 | |
| A | ASN554 | |
| B | GLN98 | |
| B | GLN199 | |
| B | ASN336 | |
| B | ASN343 | |
| B | ASN361 | |
| B | ASN367 | |
| B | ASN377 | |
| B | ASN394 | |
| A | GLN199 | |
| B | ASN448 | |
| B | ASN468 | |
| B | ASN554 | |
| A | ASN336 | |
| A | ASN343 | |
| A | ASN361 | |
| A | ASN367 | |
| A | ASN377 | |
| A | ASN394 | |
| A | ASN448 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20473317 |
| Chain | Residue | Details |
| A | ASN151 | |
| B | ASN151 |
