4UUQ

Crystal structure of human mono-glyceride lipase in complex with SAR127303

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	MONOGLYCERIDE LIPASE	polymer	320	35292.5	2	UniProt (Q99685) Pfam (PF12146) In PDB	HOMO SAPIENS (HUMAN)	MGL, HU-K5, LYSOPHOSPHOLIPASE HOMOLOG, LYSOPHOSPHOLIPASE-LIKE, MONOACYLGLYCEROL LIPASE, MAGL, MGLL
2	A, B	4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid	non-polymer		332.8	2	Chemie (64D)
3		water	water		18.0	241	Chemie (HOH)

Sequence modifications

A, B: 11 - 313 (UniProt: Q99685)

PDB	External Database	Details
Met -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Met 1	-	expression tag
Glu 2	-	expression tag
Thr 3	-	expression tag
Gly 4	-	expression tag
Pro 5	-	expression tag
Glu 6	-	expression tag
Asp 7	-	expression tag
Pro 8	-	expression tag
Ser 9	-	expression tag
Ser 10	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70585.0
Non-Polymers*	Number of molecules	2
	Total formula weight	665.6
All*	Total formula weight	71250.6

*Water molecules are not included.