4UUQ

Crystal structure of human mono-glyceride lipase in complex with SAR127303

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	lysophospholipase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006639	biological_process	acylglycerol metabolic process
A	0006954	biological_process	inflammatory response
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0019369	biological_process	arachidonic acid metabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0046464	biological_process	acylglycerol catabolic process
A	0047372	molecular_function	acylglycerol lipase activity
A	0050727	biological_process	regulation of inflammatory response
A	0051930	biological_process	regulation of sensory perception of pain
A	0052651	biological_process	monoacylglycerol catabolic process
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	2000124	biological_process	regulation of endocannabinoid signaling pathway
B	0004622	molecular_function	lysophospholipase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006639	biological_process	acylglycerol metabolic process
B	0006954	biological_process	inflammatory response
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0019369	biological_process	arachidonic acid metabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0046464	biological_process	acylglycerol catabolic process
B	0047372	molecular_function	acylglycerol lipase activity
B	0050727	biological_process	regulation of inflammatory response
B	0051930	biological_process	regulation of sensory perception of pain
B	0052651	biological_process	monoacylglycerol catabolic process
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	2000124	biological_process	regulation of endocannabinoid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	Binding site for Ligand 64D A1306 bound to SER A 132

Chain	Residue
A	GLY60
A	CYS252
A	HOH2096
A	ALA61
A	SER132
A	MET133
A	LEU158
A	ASN162
A	SER165
A	GLY220
A	LEU223

---

site_id	AC2
Number of Residues	9
Details	Binding site for Ligand 64D B1306 bound to SER B 132

Chain	Residue
B	GLY60
B	ALA61
B	SER132
B	MET133
B	LEU158
B	ASN162
B	LEU223
B	LEU224
B	HOH2107

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Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLLGHSMGG

Chain	Residue	Details
A	VAL126-GLY135

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:19957260

Chain	Residue	Details
A	SER132
B	SER132

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:19957260

Chain	Residue	Details
A	ASP249
A	HIS279
B	ASP249
B	HIS279

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35678

Chain	Residue	Details
A	THR20
B	THR20

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:O35678

Chain	Residue	Details
A	TYR68
B	TYR68

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