4UFR

Structure of the ectodomain of LGR5 in complex with R-spondin-2 (Fu1Fu2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5	polymer	484	54052.3	2	UniProt (O75473) Pfam (PF01462) Pfam (PF13855) Pfam (PF12799)	HOMO SAPIENS (HUMAN)	G-PROTEIN COUPLED RECEPTOR 49, G-PROTEIN COUPLED RECEPTOR 6 7, G-PROTEIN COUPLED RECEPTOR HG38, LGR5
2	B, D (B, D)	R-SPONDIN-2	polymer	120	13946.9	2	UniProt (Q8BFU0) Pfam (PF15913)	HOMO SAPIENS (HUMAN)	CYSTEINE-RICH AND SINGLE THROMBOSPONDIN DOMAIN-CONTAINING PROTEIN 2, CRISTIN-2, MCRISTIN-2, ROOF PLATE-SPECIFIC SPONDIN-2, RSPO2
3	E, J (A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	F, G, H, I, K... (A, B, C, D)	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
5	M, N, O, P (A, B, C, D)	water	water		18.0	150	Chemie (HOH)

Sequence modifications

A, C: 32 - 487 (UniProt: O75473)

PDB	External Database	Details
Glu 29	-	expression tag
Thr 30	-	expression tag
Gly 31	-	expression tag
Gly 545	-	expression tag
Thr 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag

A, C: 538 - 544 (UniProt: O75473)

PDB	External Database	Details
Asn 488	-	linker
Asn 489	-	linker
Gly 490	-	linker
Asn 491	-	linker
Asn 492	-	linker
Gly 493	-	linker
Asp 494	-	linker

B, D: 39 - 144 (UniProt: Q8BFU0)

PDB	External Database	Details
Glu 36	-	expression tag
Thr 37	-	expression tag
Gly 38	-	expression tag
Thr 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
His 155	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	135998.4
Non-Polymers*	Number of molecules	8
	Total formula weight	655.1
All*	Total formula weight	136653.6

*Water molecules are not included.