4UF0
Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HISTONE DEMETHYLASE UTY | polymer | 478 | 55020.4 | 1 | UniProt (O14607) Pfam (PF02373) Pfam (PF21322) Pfam (PF21326) | HOMO SAPIENS (HUMAN) | UBIQUITOUSLY-TRANSCRIBED TPR PROTEIN ON THE Y CHROMOSOME, UBIQUITOUSLY-TRANSCRIBED Y CHROMOSOME TETRATRICOPEPTIDE REPEAT PROTEIN |
| 2 | B (B) | HISTONE DEMETHYLASE UTY | polymer | 478 | 55007.4 | 1 | UniProt (O14607) Pfam (PF02373) Pfam (PF21322) Pfam (PF21326) | HOMO SAPIENS (HUMAN) | UBIQUITOUSLY-TRANSCRIBED TPR PROTEIN ON THE Y CHROMOSOME, UBIQUITOUSLY-TRANSCRIBED Y CHROMOSOME TETRATRICOPEPTIDE REPEAT PROTEIN |
| 3 | C, N (A, B) | FE (II) ION | non-polymer | 55.8 | 2 | Chemie (FE2) | |||
| 4 | D, O (A, B) | 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid | non-polymer | 306.4 | 2 | Chemie (MMK) | |||
| 5 | E, P (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | AA, BA, F, G, H... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 20 | Chemie (EDO) | |||
| 7 | CA, DA (A, B) | water | water | 18.0 | 488 | Chemie (HOH) |
Sequence modifications
A: 878 - 1347 (UniProt: O14607)
B: 878 - 1347 (UniProt: O14607)
| PDB | External Database | Details |
|---|---|---|
| Met 877 | - | expression tag |
| Ala 1348 | - | expression tag |
| Glu 1349 | - | expression tag |
| Asn 1350 | - | expression tag |
| Leu 1351 | - | expression tag |
| Tyr 1352 | - | expression tag |
| Phe 1353 | - | expression tag |
| Gln 1354 | - | expression tag |
| Glu 1272 | Asp 1272 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 877 | - | expression tag |
| Ala 1348 | - | expression tag |
| Glu 1349 | - | expression tag |
| Asn 1350 | - | expression tag |
| Leu 1351 | - | expression tag |
| Tyr 1352 | - | expression tag |
| Phe 1353 | - | expression tag |
| Gln 1354 | - | expression tag |
| Glu 1332 | Gln 1332 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 110027.8 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 2096.6 | |
| All* | Total formula weight | 112124.4 |
