Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4UF0

Crystal structure of JmjC domain of human histone demethylase UTY in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid.

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FE2 A 2267
ChainResidue
AHIS1093
AGLU1095
AHIS1173
AHOH2128
AMMK2268

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE MMK A 2268
ChainResidue
AHIS1093
AGLU1095
AASN1096
AASN1103
ATRP1113
AHIS1173
AVAL1175
AHOH2115
AHOH2128
AHOH2184
AFE22267
APHE1031
AGLN1080
ALYS1084
ATHR1090

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 2269
ChainResidue
ACYS1278
ACYS1281
ACYS1305
ACYS1308

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FE2 B 2267
ChainResidue
BHIS1093
BGLU1095
BHIS1173
BHOH2126
BMMK2268

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE MMK B 2268
ChainResidue
BPHE1031
BTYR1082
BLYS1084
BTHR1090
BHIS1093
BGLU1095
BASN1096
BASN1103
BTRP1113
BHIS1173
BVAL1175
BHOH2126
BFE22267
BEDO2276

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 2269
ChainResidue
BCYS1278
BCYS1281
BCYS1305
BCYS1308

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 2270
ChainResidue
ALYS895
BVAL1123
BASP1126
BPHE1127
BHOH2258

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO B 2271
ChainResidue
BGLN986
BTRP1180
BHOH2064

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 2270
ChainResidue
ATHR908
AASN1168
AALA1169
ATHR1192
ACYS1194
AHOH2144

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 2271
ChainResidue
ATHR1252
AALA1256
BPHE1236
BGLU1237

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 2272
ChainResidue
APHE990
BGLY919
BASP1163
BHOH2017
BHOH2151

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 2273
ChainResidue
AGLU1294
BHIS943
BMET944
BASP1036
BEDO2274

site_idBC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 2274
ChainResidue
BHIS943
BMET944
BGLU946
BASN1034
BILE1035
BASP1036
BEDO2273

site_idBC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO B 2275
ChainResidue
BPRO910
BPRO913
BASN1168
BALA1169
BCYS1194
BLEU1198
BHOH2135
BHOH2136
BEDO2281

site_idBC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO B 2276
ChainResidue
BGLY1075
BTYR1082
BGLU1095
BSER1101
BALA1185
BASN1187
BHOH2131
BMMK2268

site_idBC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 2277
ChainResidue
BHIS1071
BPRO1214
BTYR1277
BHOH2209

site_idBC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 2278
ChainResidue
BILE967
BTRP968
BARG969
BASN1131
BHOH2259

site_idBC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 2272
ChainResidue
ASER932
ATHR933
AGLN986
AGLY1107
APRO1108
AASN1182
AEDO2273
AEDO2275

site_idCC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 2273
ChainResidue
AGLN986
APHE990
ATRP1180
AHOH2066
AEDO2272

site_idCC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 2279
ChainResidue
BASN1223
BARG1226
BARG1269
BASN1271
BHOH2174

site_idCC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO B 2280
ChainResidue
BTHR1252
BGLU1255
BALA1256

site_idCC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 2281
ChainResidue
BTHR908
BASN1168
BALA1169
BTHR1192
BCYS1194
BEDO2275

site_idCC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 2274
ChainResidue
AASN884
AARG1156
AHOH2002
AHOH2003
BGLU997
BASN998
BGLU999

site_idCC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 2275
ChainResidue
ALEU928
AGLY929
ASER932
AILE1106
AGLY1107
APRO1108
AEDO2272

site_idCC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 2276
ChainResidue
AGLU999
AHOH2072
BASN884

site_idCC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 2277
ChainResidue
AHIS1267
AHIS1276
ATYR1301

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues326
DetailsDomain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24798337","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24798337","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

PDB statisticsPDBj update infoContact PDBjnumon