4UDD
GR in complex with desisobutyrylciclesonide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GLUCOCORTICOID RECEPTOR | polymer | 280 | 32187.1 | 1 | UniProt (P04150) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | GR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1 |
| 2 | B (B) | NUCLEAR RECEPTOR COACTIVATOR 2 | polymer | 14 | 1708.9 | 1 | UniProt (Q15596) | HOMO SAPIENS | NCOA-2, CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 75, BHLHE75, TRANSCRIPTIONAL INTERMEDIARY FACTOR 2, HTIF2, NCOA2 |
| 3 | C, D, E (A) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 3 | Chemie (CPS) PubChem (16396400) PubChem (18397788) PubChem (177530666) PubChem (24883538) PubChem (457060) PubChem (44120060) PubChem (44450441) PubChem (50987450) PubChem (51028881) PubChem (51028882) PubChem (53393728) PubChem (3659871) PubChem (58528211) PubChem (53229977) PubChem (107670) PubChem (71774074) PubChem (9895216) PubChem (10371606) PubChem (90488808) PubChem (91746229) PubChem (91809267) PubChem (102565428) PubChem (122361936) PubChem (122362044) PubChem (131632459) PubChem (133645855) PubChem (137704711) PubChem (146159681) | |||
| 4 | F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | G (A) | DESISOBUYTYRYL CICLESONIDE | non-polymer | 470.6 | 1 | Chemie (CV7) PubChem (24970203) PubChem (24848783) PubChem (46781139) PubChem (145626712) PubChem (58363227) PubChem (67006594) PubChem (59475695) PubChem (68616189) PubChem (68616392) PubChem (59664268) PubChem (90246358) PubChem (11328899) PubChem (6918281) PubChem (124225844) PubChem (124429290) PubChem (143619630) PubChem (11202231) PubChem (118387944) PubChem (133688038) PubChem (122361612) PubChem (124429289) PubChem (124519407) PubChem (146157455) PubChem (157499838) PubChem (157576483) PubChem (162214290) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | expression tag |
| Ser 499 | - | expression tag |
| Asp 517 | Asn 517 | engineered mutation |
| Met 571 | Val 571 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33896.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2377.3 | |
| All* | Total formula weight | 36273.4 |
