4UDB

MR in complex with desisobutyrylciclesonide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	MINERALOCORTICOID RECEPTOR	polymer	272	31739.4	1	UniProt (P08235) Pfam (PF00104) In PDB	HOMO SAPIENS (HUMAN)	MR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 2
2	B	NUCLEAR RECEPTOR COACTIVATOR 1	polymer	15	1726.0	1	UniProt (Q15788) In PDB	HOMO SAPIENS (HUMAN)	NCOA-1, CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 74, BHLHE74, PROTEIN HIN-2, RIP160, RENAL CARCINOMA ANTIGEN NY-REN-52, STEROID RECEPTOR COACTIVATOR 1, SRC-1, NCOA1 PEPTIDE
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	A	DESISOBUYTYRYL CICLESONIDE	non-polymer		470.6	1	Chemie (CV7)
7		water	water		18.0	60	Chemie (HOH)

Sequence modifications

A: 735 - 984 (UniProt: P08235)

PDB	External Database	Details
Met 713	-	expression tag
His 714	-	expression tag
Asn 715	-	expression tag
His 716	-	expression tag
Asn 717	-	expression tag
His 718	-	expression tag
Asn 719	-	expression tag
His 720	-	expression tag
Asn 721	-	expression tag
His 722	-	expression tag
Asn 723	-	expression tag
His 724	-	expression tag
Asn 725	-	expression tag
Gly 726	-	expression tag
Gly 727	-	expression tag
Glu 728	-	expression tag
Asn 729	-	expression tag
Leu 730	-	expression tag
Tyr 731	-	expression tag
Phe 732	-	expression tag
Gln 733	-	expression tag
Gly 734	-	expression tag
Ser 808	Cys 808	engineered mutation
Leu 810	Ser 810	engineered mutation
Ser 910	Cys 910	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33465.4
Non-Polymers*	Number of molecules	4
	Total formula weight	736.9
All*	Total formula weight	34202.2

*Water molecules are not included.