4UDB
MR in complex with desisobutyrylciclesonide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MINERALOCORTICOID RECEPTOR | polymer | 272 | 31739.4 | 1 | UniProt (P08235) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | MR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 2 |
| 2 | B (B) | NUCLEAR RECEPTOR COACTIVATOR 1 | polymer | 15 | 1726.0 | 1 | UniProt (Q15788) | HOMO SAPIENS (HUMAN) | NCOA-1, CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 74, BHLHE74, PROTEIN HIN-2, RIP160, RENAL CARCINOMA ANTIGEN NY-REN-52, STEROID RECEPTOR COACTIVATOR 1, SRC-1, NCOA1 PEPTIDE |
| 3 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) PubChem (679) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | F (A) | DESISOBUYTYRYL CICLESONIDE | non-polymer | 470.6 | 1 | Chemie (CV7) PubChem (24970203) PubChem (24848783) PubChem (46781139) PubChem (145626712) PubChem (58363227) PubChem (67006594) PubChem (59475695) PubChem (68616189) PubChem (68616392) PubChem (59664268) PubChem (90246358) PubChem (11328899) PubChem (6918281) PubChem (124225844) PubChem (124429290) PubChem (143619630) PubChem (11202231) PubChem (118387944) PubChem (133688038) PubChem (122361612) PubChem (124429289) PubChem (124519407) PubChem (146157455) PubChem (157499838) PubChem (157576483) PubChem (162214290) | |||
| 7 | G, H (A, B) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 735 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Met 713 | - | expression tag |
| His 714 | - | expression tag |
| Asn 715 | - | expression tag |
| His 716 | - | expression tag |
| Asn 717 | - | expression tag |
| His 718 | - | expression tag |
| Asn 719 | - | expression tag |
| His 720 | - | expression tag |
| Asn 721 | - | expression tag |
| His 722 | - | expression tag |
| Asn 723 | - | expression tag |
| His 724 | - | expression tag |
| Asn 725 | - | expression tag |
| Gly 726 | - | expression tag |
| Gly 727 | - | expression tag |
| Glu 728 | - | expression tag |
| Asn 729 | - | expression tag |
| Leu 730 | - | expression tag |
| Tyr 731 | - | expression tag |
| Phe 732 | - | expression tag |
| Gln 733 | - | expression tag |
| Gly 734 | - | expression tag |
| Ser 808 | Cys 808 | engineered mutation |
| Leu 810 | Ser 810 | engineered mutation |
| Ser 910 | Cys 910 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33465.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 736.9 | |
| All* | Total formula weight | 34202.2 |
