4U7T
Crystal structure of DNMT3A-DNMT3L in complex with histone H3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | DNA (cytosine-5)-methyltransferase 3A | polymer | 445 | 50878.4 | 2 | UniProt (Q9Y6K1) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (Human) | DNA methyltransferases DNMT3A |
| 2 | B, D (B, D) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24119.7 | 2 | UniProt (Q9UJW3) | Homo sapiens (Human) | DNA methyltransferases DNMT3L |
| 3 | E, F (F, G) | peptide from Histone H3.3 | polymer | 12 | 1308.5 | 2 | UniProt (P84243) | Homo sapiens | histone H3 peptide |
| 4 | G, H, I, K, L... (A, C) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | J, N (A, C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 6 | O, P, Q (A, C, D) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, C: 476 - 912 (UniProt: Q9Y6K1)
B, D: 178 - 379 (UniProt: Q9UJW3)
| PDB | External Database | Details |
|---|---|---|
| Gly 468 | - | expression tag |
| Pro 469 | - | expression tag |
| Leu 470 | - | expression tag |
| Gly 471 | - | expression tag |
| Ser 472 | - | expression tag |
| Pro 473 | - | expression tag |
| Glu 474 | - | expression tag |
| Phe 475 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
| Pro 172 | - | expression tag |
| Leu 173 | - | expression tag |
| Gly 174 | - | expression tag |
| Ser 175 | - | expression tag |
| Glu 176 | - | expression tag |
| Phe 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 152613.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1161.3 | |
| All* | Total formula weight | 153774.4 |
