4U7T
Crystal structure of DNMT3A-DNMT3L in complex with histone H3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | DNA (cytosine-5)-methyltransferase 3A | polymer | 445 | 50878.4 | 2 | UniProt (Q9Y6K1) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (Human) | DNA methyltransferases DNMT3A |
| 2 | B, D (B, D) | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24119.7 | 2 | UniProt (Q9UJW3) | Homo sapiens (Human) | DNA methyltransferases DNMT3L |
| 3 | E, F (F, G) | peptide from Histone H3.3 | polymer | 12 | 1308.5 | 2 | UniProt (P84243) | Homo sapiens | histone H3 peptide |
| 4 | G, H, I, K, L... (A, C) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | J, N (A, C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (6419189) PubChem (52224398) PubChem (57544532) PubChem (164157219) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (126969526) PubChem (71170554) PubChem (129105892) PubChem (13231890) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 6 | O, P, Q (A, C, D) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, C: 476 - 912 (UniProt: Q9Y6K1)
B, D: 178 - 379 (UniProt: Q9UJW3)
| PDB | External Database | Details |
|---|---|---|
| Gly 468 | - | expression tag |
| Pro 469 | - | expression tag |
| Leu 470 | - | expression tag |
| Gly 471 | - | expression tag |
| Ser 472 | - | expression tag |
| Pro 473 | - | expression tag |
| Glu 474 | - | expression tag |
| Phe 475 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
| Pro 172 | - | expression tag |
| Leu 173 | - | expression tag |
| Gly 174 | - | expression tag |
| Ser 175 | - | expression tag |
| Glu 176 | - | expression tag |
| Phe 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 152613.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1161.3 | |
| All* | Total formula weight | 153774.4 |
