4U5B
Crystal structure of GluA2 A622T, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glutamate receptor 2 | polymer | 814 | 91415.3 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
2 | E, F | Con-ikot-ikot | polymer | 90 | 9753.2 | 2 | UniProt (P0CB20) In PDB | Conus striatus (Striated cone) | |
3 | A, B, C, D | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE | non-polymer | 213.2 | 4 | Chemie (KAI) | |||
4 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
5 | B, D | N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | non-polymer | 480.7 | 2 | Chemie (FWF) |
Sequence modifications
A, B, C, D: 6 - 824 (UniProt: P19491)
E, F: 1 - 86 (UniProt: P0CB20)
PDB | External Database | Details |
---|---|---|
Gly 184 | Lys 203 | engineered mutation |
Glu 237 | Asn 256 | engineered mutation |
- | Leu 402 | deletion |
- | Pro 403 | deletion |
Asp 385 | Asn 406 | engineered mutation |
Gln 392 | Asn 413 | engineered mutation |
Asp 461 | Asn 482 | engineered mutation |
Ala 528 | Cys 549 | engineered mutation |
Leu 535 | Gly 556 | engineered mutation |
- | Arg 581 | deletion |
- | Glu 582 | deletion |
- | Thr 583 | deletion |
- | Gln 584 | deletion |
- | Ser 585 | deletion |
Glu 565 | Ser 586 | engineered mutation |
Phe 577 | Leu 598 | engineered mutation |
Ala 580 | Ser 601 | engineered mutation |
Lys 582 | Gly 603 | engineered mutation |
Leu 583 | Ala 604 | engineered mutation |
Phe 585 | Met 606 | engineered mutation |
Ala 589 | Cys 610 | engineered mutation |
Ala 598 | Gly 619 | engineered mutation |
Ala 602 | Gly 623 | engineered mutation |
Thr 622 | Ala 643 | engineered mutation |
Ala 815 | Cys 836 | engineered mutation |
Arg 818 | Ser 839 | engineered mutation |
Met 819 | Arg 840 | engineered mutation |
Lys 820 | Ala 841 | engineered mutation |
Leu 821 | Glu 842 | engineered mutation |
Val 822 | Ala 843 | engineered mutation |
Pro 823 | Lys 844 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Pro -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 385167.7 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 2699.1 | |
All* | Total formula weight | 387866.8 |