4U4S
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM25 at 1.90 A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor 2,Glutamate receptor 2 | polymer | 263 | 29244.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | C, N (A, B) | 4-ethyl-3,4-dihydro-2H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide | non-polymer | 213.3 | 2 | Chemie (3C1) | |||
| 3 | D, E, O (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, G, P, Q (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | H, I, J, K, S... (A, B) | ACETATE ION | non-polymer | 59.0 | 8 | Chemie (ACT) | |||
| 6 | L, W (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | M, X (A, B) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
| 8 | R (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 9 | Y, Z (A, B) | water | water | 18.0 | 402 | Chemie (HOH) |
Sequence modifications
A, B: 392 - 506 (UniProt: P19491)
A, B: 632 - 775 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 390 | - | expression tag |
| Ala 391 | - | expression tag |
| Tyr 483 | Leu 504 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 507 | - | linker |
| Thr 508 | - | linker |
| Ser 754 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58489.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2026.7 | |
| All* | Total formula weight | 60516.1 |
