4U4S

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM25 at 1.90 A resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 3C1 A 801

Chain	Residue
A	PRO494
B	LEU751
B	SER754
A	SER729
A	LYS730
A	GLY731
B	LYS493
B	PRO494
B	PHE495
B	MET496
B	SER497

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 802

Chain	Residue
A	ASP651
A	SER652
A	LYS656
A	ARG660
A	HOH973
A	HOH999
A	HOH1060
A	HOH1085

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 803

Chain	Residue
A	ARG661
A	HOH1081
B	LYS752

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 804

Chain	Residue
A	CYS436
A	LEU742
A	ALA745

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 805

Chain	Residue
A	ARG660
A	TRP671
A	ARG675
A	HOH1090

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ACT A 806

Chain	Residue
A	HIS435
A	ALA749
A	HOH992
B	TYR483

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ACT A 807

Chain	Residue
A	MET496
A	SER497
A	HOH984
A	HOH1002
B	SER729
B	3C1801

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ACT A 808

Chain	Residue
A	ARG420
A	HOH902
A	HOH969
B	LYS695

---

site_id	AC9
Number of Residues	6
Details	binding site for residue ACT A 809

Chain	Residue
A	GLU486
A	ASP490
A	PHE491
B	LYS493
B	ASN747
B	HOH1091

---

site_id	AD1
Number of Residues	1
Details	binding site for residue CL A 810

Chain	Residue
A	ALA665

---

site_id	AD2
Number of Residues	13
Details	binding site for residue GLU A 811

Chain	Residue
A	TYR450
A	PRO478
A	LEU479
A	THR480
A	ARG485
A	GLY653
A	SER654
A	THR655
A	GLU705
A	TYR732
A	HOH949
A	HOH956
A	HOH1064

---

site_id	AD3
Number of Residues	11
Details	binding site for residue 3C1 B 801

Chain	Residue
A	LYS493
A	PRO494
A	PHE495
A	MET496
A	SER754
A	ACT807
B	PRO494
B	SER729
B	LYS730
B	GLY731
B	HOH1082

---

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 B 802

Chain	Residue
B	SER652
B	LYS656
B	ARG660
B	ACT807
B	HOH980
B	HOH1070
B	HOH1088

---

site_id	AD5
Number of Residues	9
Details	binding site for residue GOL B 803

Chain	Residue
B	GLY451
B	ALA452
B	ARG453
B	TRP460
B	ARG485
B	GLU657
B	HOH1006
B	HOH1008
B	HOH1070

---

site_id	AD6
Number of Residues	4
Details	binding site for residue GOL B 804

Chain	Residue
B	ARG660
B	TRP671
B	ARG675
B	ACT807

---

site_id	AD7
Number of Residues	4
Details	binding site for residue PEG B 805

Chain	Residue
B	GLU416
B	GLY417
B	ARG420
B	HOH1101

---

site_id	AD8
Number of Residues	3
Details	binding site for residue ACT B 806

Chain	Residue
B	ARG420
B	HOH1047
B	HIS412

---

site_id	AD9
Number of Residues	7
Details	binding site for residue ACT B 807

Chain	Residue
B	LYS656
B	ARG660
B	ARG675
B	PHE682
B	SO4802
B	GOL804
B	HOH1089

---

site_id	AE1
Number of Residues	5
Details	binding site for residue ACT B 808

Chain	Residue
A	SER729
B	MET496
B	SER497
B	HOH984
B	HOH1054

---

site_id	AE2
Number of Residues	5
Details	binding site for residue ACT B 809

Chain	Residue
A	LYS493
A	HOH1087
B	GLU486
B	ASP490
B	PHE491

---

site_id	AE3
Number of Residues	2
Details	binding site for residue CL B 810

Chain	Residue
B	LYS393
B	THR394

---

site_id	AE4
Number of Residues	14
Details	binding site for residue GLU B 811

Chain	Residue
B	TYR450
B	PRO478
B	LEU479
B	THR480
B	ARG485
B	LEU650
B	GLY653
B	SER654
B	THR655
B	GLU705
B	TYR732
B	HOH955
B	HOH970
B	HOH979

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---