Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 3C1 A 801 |
| Chain | Residue |
| A | PRO494 |
| B | LEU751 |
| B | SER754 |
| A | SER729 |
| A | LYS730 |
| A | GLY731 |
| B | LYS493 |
| B | PRO494 |
| B | PHE495 |
| B | MET496 |
| B | SER497 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 802 |
| Chain | Residue |
| A | ASP651 |
| A | SER652 |
| A | LYS656 |
| A | ARG660 |
| A | HOH973 |
| A | HOH999 |
| A | HOH1060 |
| A | HOH1085 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 803 |
| Chain | Residue |
| A | ARG661 |
| A | HOH1081 |
| B | LYS752 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 804 |
| Chain | Residue |
| A | CYS436 |
| A | LEU742 |
| A | ALA745 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 805 |
| Chain | Residue |
| A | ARG660 |
| A | TRP671 |
| A | ARG675 |
| A | HOH1090 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 806 |
| Chain | Residue |
| A | HIS435 |
| A | ALA749 |
| A | HOH992 |
| B | TYR483 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 807 |
| Chain | Residue |
| A | MET496 |
| A | SER497 |
| A | HOH984 |
| A | HOH1002 |
| B | SER729 |
| B | 3C1801 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 808 |
| Chain | Residue |
| A | ARG420 |
| A | HOH902 |
| A | HOH969 |
| B | LYS695 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 809 |
| Chain | Residue |
| A | GLU486 |
| A | ASP490 |
| A | PHE491 |
| B | LYS493 |
| B | ASN747 |
| B | HOH1091 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 810 |
| site_id | AD2 |
| Number of Residues | 13 |
| Details | binding site for residue GLU A 811 |
| Chain | Residue |
| A | TYR450 |
| A | PRO478 |
| A | LEU479 |
| A | THR480 |
| A | ARG485 |
| A | GLY653 |
| A | SER654 |
| A | THR655 |
| A | GLU705 |
| A | TYR732 |
| A | HOH949 |
| A | HOH956 |
| A | HOH1064 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue 3C1 B 801 |
| Chain | Residue |
| A | LYS493 |
| A | PRO494 |
| A | PHE495 |
| A | MET496 |
| A | SER754 |
| A | ACT807 |
| B | PRO494 |
| B | SER729 |
| B | LYS730 |
| B | GLY731 |
| B | HOH1082 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 802 |
| Chain | Residue |
| B | SER652 |
| B | LYS656 |
| B | ARG660 |
| B | ACT807 |
| B | HOH980 |
| B | HOH1070 |
| B | HOH1088 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 803 |
| Chain | Residue |
| B | GLY451 |
| B | ALA452 |
| B | ARG453 |
| B | TRP460 |
| B | ARG485 |
| B | GLU657 |
| B | HOH1006 |
| B | HOH1008 |
| B | HOH1070 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 804 |
| Chain | Residue |
| B | ARG660 |
| B | TRP671 |
| B | ARG675 |
| B | ACT807 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 805 |
| Chain | Residue |
| B | GLU416 |
| B | GLY417 |
| B | ARG420 |
| B | HOH1101 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 806 |
| Chain | Residue |
| B | ARG420 |
| B | HOH1047 |
| B | HIS412 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 807 |
| Chain | Residue |
| B | LYS656 |
| B | ARG660 |
| B | ARG675 |
| B | PHE682 |
| B | SO4802 |
| B | GOL804 |
| B | HOH1089 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 808 |
| Chain | Residue |
| A | SER729 |
| B | MET496 |
| B | SER497 |
| B | HOH984 |
| B | HOH1054 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 809 |
| Chain | Residue |
| A | LYS493 |
| A | HOH1087 |
| B | GLU486 |
| B | ASP490 |
| B | PHE491 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 810 |
| Chain | Residue |
| B | LYS393 |
| B | THR394 |
| site_id | AE4 |
| Number of Residues | 14 |
| Details | binding site for residue GLU B 811 |
| Chain | Residue |
| B | TYR450 |
| B | PRO478 |
| B | LEU479 |
| B | THR480 |
| B | ARG485 |
| B | LEU650 |
| B | GLY653 |
| B | SER654 |
| B | THR655 |
| B | GLU705 |
| B | TYR732 |
| B | HOH955 |
| B | HOH970 |
| B | HOH979 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | PRO478 | |
| B | SER654 | |
| B | THR655 | |
| B | GLU705 | |
| A | THR480 | |
| A | ARG485 | |
| A | SER654 | |
| A | THR655 | |
| A | GLU705 | |
| B | PRO478 | |
| B | THR480 | |
| B | ARG485 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG453 | |
| A | ARG660 | |
| A | LYS752 | |
| B | ARG453 | |
| B | ARG660 | |
| B | LYS752 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE633 | |
| B | ILE633 | |
| Chain | Residue | Details |
| A | SER662 | |
| B | SER662 | |
| Chain | Residue | Details |
| A | SER696 | |
| B | SER696 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN392 | |
| B | ASN392 | |
