4U1X

Full length GluA2-kainate-(R,R)-2b complex crystal form B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2	polymer	824	92574.7	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	A, B, C, D	3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE	non-polymer		213.2	4	Chemie (KAI)
3	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
4	B, D	N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide	non-polymer		480.7	2	Chemie (FWF)
5	D	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)

Sequence modifications

A, B, C, D: 8 - 826 (UniProt: P19491)

PDB	External Database	Details
Glu 239	Asn 256	engineered mutation
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
-	Gly 405	deletion
Asp 385	Asn 406	engineered mutation
Gln 392	Asn 413	engineered mutation
Ala 528	Cys 549	engineered mutation
Leu 535	Gly 556	engineered mutation
Phe 577	Leu 598	engineered mutation
Ala 580	Ser 601	engineered mutation
Lys 582	Gly 603	engineered mutation
Leu 583	Ala 604	engineered mutation
Phe 585	Met 606	engineered mutation
Ala 589	Cys 610	engineered mutation
Ala 598	Gly 619	engineered mutation
Ala 602	Gly 623	engineered mutation
Ala 815	Cys 836	engineered mutation
Gly 827	-	expression tag
Leu 828	-	expression tag
Val 829	-	expression tag
Pro 830	-	expression tag
Arg 831	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	370298.8
Non-Polymers*	Number of molecules	11
	Total formula weight	2894.4
All*	Total formula weight	373193.2

*Water molecules are not included.