4U1N
HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, B-42 alpha chain | polymer | 278 | 32123.2 | 1 | UniProt (P30480) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P01889) | Homo sapiens (Human) | MHC class I antigen B*42 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | Protein Nef | polymer | 9 | 1095.4 | 1 | UniProt (Q90VG9) UniProt (by SIFTS) (P03407) | Human immunodeficiency virus 1 | |
| 4 | D, E, F, G, H... (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 5 | N, O (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | R, S, T (A, B, C) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A: 1 - 277 (UniProt: P30480)
B: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| His 9 | Tyr 33 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45097.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 929.0 | |
| All* | Total formula weight | 46026.9 |
