4TWK
Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium channel subfamily K member 2 | polymer | 283 | 31229.4 | 2 | UniProt (O95069) Pfam (PF07885) | Homo sapiens (Human) | Outward rectifying potassium channel protein TREK-1,TREK-1 K(+) channel subunit,Two pore domain potassium channel TREK-1,Two pore potassium channel TPKC1 |
| 2 | C, D, J (A, B) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) | |||
| 3 | E, F, G, H, L (A, B) | Octyl Glucose Neopentyl Glycol | non-polymer | 568.7 | 5 | Chemie (37X) | |||
| 4 | I (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | K (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A, B: 26 - 300 (UniProt: O95069)
| PDB | External Database | Details |
|---|---|---|
| Met 25 | - | initiating methionine |
| Ala 301 | - | expression tag |
| Glu 302 | - | expression tag |
| Asn 303 | - | expression tag |
| Leu 304 | - | expression tag |
| Tyr 305 | - | expression tag |
| Phe 306 | - | expression tag |
| Gln 307 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62458.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3206.3 | |
| All* | Total formula weight | 65665.1 |
