4TV1
Crystal structure of hERa-LBD (Y537S) in complex with propylparaben
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 251 | 28672.7 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (B) | Estrogen receptor | polymer | 251 | 28656.7 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (C, D) | Nuclear receptor coactivator 1 | polymer | 13 | 1591.9 | 2 | UniProt (by SIFTS) (Q15788) | Homo sapiens | NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1, Coactivator peptide SRC-1 |
| 4 | E, L (A, B) | propyl 4-hydroxybenzoate | non-polymer | 180.2 | 2 | Chemie (36M) | |||
| 5 | F, G, K, M, N (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | H, I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | J, O (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 8 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A: 302 - 552 (UniProt: P03372)
B: 302 - 552 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60513.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1157.2 | |
| All* | Total formula weight | 61670.5 |
