4TNW

C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Avermectin-sensitive glutamate-gated chloride channel GluCl alpha	polymer	347	39636.6	10	UniProt (G5EBR3) Pfam (PF02931) Pfam (PF02932) In PDB	Caenorhabditis elegans	Protein GLC-1
2	F, G, H, I, U...	Mouse monoclonal Fab fragment, heavy chain	polymer	224	24297.2	10		Mus musculus
3	K, L, N, O, Z...	Mouse monoclonal Fab fragment, light chain	polymer	215	23151.7	10		Mus musculus
4	T, A, B, C, D...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG)
5	T, A, D, P, Q...	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	7	Chemie (POV)
6	A, P	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
7	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
8	S, T, B, C, D...	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	7	Chemie (LMT)

Sequence modifications

A, B, C, D, E, P, Q, R, S, T: 1 - 302 (UniProt: G5EBR3)
A, B, C, D, E, P, Q, R, S, T: 306 - 339 (UniProt: G5EBR3)

PDB	External Database	Details
Ala 303	-	linker
Gly 304	-	linker
Thr 305	-	linker
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	30
	Total formula weight	870855.4
Non-Polymers*	Number of molecules	26
	Total formula weight	11048.7
All*	Total formula weight	881904.1

*Water molecules are not included.