4TNV

C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Avermectin-sensitive glutamate-gated chloride channel GluCl alpha	polymer	347	39636.6	10	UniProt (G5EBR3) Pfam (PF02931) Pfam (PF02932)	Caenorhabditis elegans	Protein GLC-1
2	BA, CA, F, G, H... (F, G, H, U, V...)	Mouse monoclonal Fab fragment, heavy chain	polymer	224	24297.2	10		Mus musculus
3	AA, DA, I, J, K... (K, L, N, O, Z...)	Mouse monoclonal Fab fragment, light chain	polymer	215	23151.7	10		Mus musculus
4	EA, HA, JA, LA, NA... (A, B, C, D, E...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)
5	AB, FA, IA, KA, MA... (T, A, B, C, D...)	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	10	Chemie (LMT)
6	BB, GA (T, A)	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
7	RA, SA (P)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)

Sequence modifications

A, B, C, D, E, P, Q, R, S, T: 1 - 302 (UniProt: G5EBR3)
A, B, C, D, E, P, Q, R, S, T: 306 - 339 (UniProt: G5EBR3)

PDB	External Database	Details
Ala 303	-	linker
Gly 304	-	linker
Thr 305	-	linker
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	30
	Total formula weight	870855.4
Non-Polymers*	Number of molecules	24
	Total formula weight	7767.3
All*	Total formula weight	878622.7

*Water molecules are not included.