Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4TNV

C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
P	0004888	molecular_function	transmembrane signaling receptor activity
P	0005216	molecular_function	monoatomic ion channel activity
P	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
P	0006811	biological_process	monoatomic ion transport
P	0016020	cellular_component	membrane
P	0034220	biological_process	monoatomic ion transmembrane transport
Q	0004888	molecular_function	transmembrane signaling receptor activity
Q	0005216	molecular_function	monoatomic ion channel activity
Q	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
Q	0006811	biological_process	monoatomic ion transport
Q	0016020	cellular_component	membrane
Q	0034220	biological_process	monoatomic ion transmembrane transport
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0005216	molecular_function	monoatomic ion channel activity
R	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
R	0006811	biological_process	monoatomic ion transport
R	0016020	cellular_component	membrane
R	0034220	biological_process	monoatomic ion transmembrane transport
S	0004888	molecular_function	transmembrane signaling receptor activity
S	0005216	molecular_function	monoatomic ion channel activity
S	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
S	0006811	biological_process	monoatomic ion transport
S	0016020	cellular_component	membrane
S	0034220	biological_process	monoatomic ion transmembrane transport
T	0004888	molecular_function	transmembrane signaling receptor activity
T	0005216	molecular_function	monoatomic ion channel activity
T	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
T	0006811	biological_process	monoatomic ion transport
T	0016020	cellular_component	membrane
T	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMyLqyYPmDvqqC

Chain	Residue	Details
A	CYS130-CYS144

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
i	TYR194-HIS200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:21572436, ECO:0000269\|PubMed:25143115

Chain	Residue	Details
A	PHE215-PHE237
T	PHE215-PHE237
B	PHE215-PHE237
C	PHE215-PHE237
D	PHE215-PHE237
E	PHE215-PHE237
P	PHE215-PHE237
Q	PHE215-PHE237
R	PHE215-PHE237
S	PHE215-PHE237

site_id	SWS_FT_FI2
Number of Residues	40
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:21572436, ECO:0000269\|PubMed:25143115

Chain	Residue	Details
A	ASP238-ILE242
T	ASP238-ILE242
B	ASP238-ILE242
C	ASP238-ILE242
D	ASP238-ILE242
E	ASP238-ILE242
P	ASP238-ILE242
Q	ASP238-ILE242
R	ASP238-ILE242
S	ASP238-ILE242

site_id	SWS_FT_FI3
Number of Residues	210
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:21572436, ECO:0000269\|PubMed:25143115

Chain	Residue	Details
A	PRO243-ASN264
T	PRO243-ASN264
B	PRO243-ASN264
C	PRO243-ASN264
D	PRO243-ASN264
E	PRO243-ASN264
P	PRO243-ASN264
Q	PRO243-ASN264
R	PRO243-ASN264
S	PRO243-ASN264

site_id	SWS_FT_FI4
Number of Residues	60
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:21572436, ECO:0000269\|PubMed:25143115

Chain	Residue	Details
A	SER265-SER271
T	SER265-SER271
B	SER265-SER271
C	SER265-SER271
D	SER265-SER271
E	SER265-SER271
P	SER265-SER271
Q	SER265-SER271
R	SER265-SER271
S	SER265-SER271

site_id	SWS_FT_FI5
Number of Residues	200
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:21572436, ECO:0000269\|PubMed:25143115

Chain	Residue	Details
A	TYR272-LEU292
T	TYR272-LEU292
B	TYR272-LEU292
C	TYR272-LEU292
D	TYR272-LEU292
E	TYR272-LEU292
P	TYR272-LEU292
Q	TYR272-LEU292
R	TYR272-LEU292
S	TYR272-LEU292

site_id	SWS_FT_FI6
Number of Residues	210
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:21572436, ECO:0000269\|PubMed:25143115

Chain	Residue	Details
A	LEU317-PHE338
T	LEU317-PHE338
B	LEU317-PHE338
C	LEU317-PHE338
D	LEU317-PHE338
E	LEU317-PHE338
P	LEU317-PHE338
Q	LEU317-PHE338
R	LEU317-PHE338
S	LEU317-PHE338

site_id	SWS_FT_FI7
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269\|PubMed:21572436

Chain	Residue	Details
A	ARG37
C	ARG56
C	SER121
C	SER150
D	ARG37
D	ARG56
D	SER121
D	SER150
E	ARG37
E	ARG56
E	SER121
A	ARG56
E	SER150
P	ARG37
P	ARG56
P	SER121
P	SER150
Q	ARG37
Q	ARG56
Q	SER121
Q	SER150
R	ARG37
A	SER121
R	ARG56
R	SER121
R	SER150
S	ARG37
S	ARG56
S	SER121
S	SER150
T	ARG37
T	ARG56
T	SER121
A	SER150
T	SER150
B	ARG37
B	ARG56
B	SER121
B	SER150
C	ARG37

site_id	SWS_FT_FI8
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:21572436, ECO:0000269\|PubMed:25143115

Chain	Residue	Details
A	ASN185
T	ASN185
B	ASN185
C	ASN185
D	ASN185
E	ASN185
P	ASN185
Q	ASN185
R	ASN185
S	ASN185

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)