4TNT

Structure of the human mineralocorticoid receptor in complex with DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mineralocorticoid receptor	polymer	103	11285.9	2	UniProt (P08235) Pfam (PF00105) In PDB	Homo sapiens (Human)	MR,Nuclear receptor subfamily 3 group C member 2
2	C	DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3')	polymer	17	5162.4	1		synthetic construct
3	D	DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3')	polymer	17	5251.4	1		synthetic construct
4	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, B: 593 - 671 (UniProt: P08235)

PDB	External Database	Details
Met 569	-	initiating methionine
His 570	-	expression tag
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
Ser 576	-	expression tag
Ser 577	-	expression tag
Gly 578	-	expression tag
Val 579	-	expression tag
Asp 580	-	expression tag
Leu 581	-	expression tag
Gly 582	-	expression tag
Thr 583	-	expression tag
Glu 584	-	expression tag
Asn 585	-	expression tag
Leu 586	-	expression tag
Tyr 587	-	expression tag
Phe 588	-	expression tag
Gln 589	-	expression tag
Ser 590	-	expression tag
Asn 591	-	expression tag
Ala 592	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	32985.6
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	33247.2

*Water molecules are not included.