4TLS

Crystal Structure of Human Transthyretin Glu92Pro Mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Transthyretin	polymer	125	13887.6	2	UniProt (P02766) Pfam (PF00576) In PDB	Homo sapiens (Human)	ATTR,Prealbumin,TBPA
2	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5		water	water		18.0	111	Chemie (HOH)

Sequence modifications

A, B: 9 - 127 (UniProt: P02766)

PDB	External Database	Details
Pro 92	Glu 112	engineered mutation
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27775.1
Non-Polymers*	Number of molecules	4
	Total formula weight	305.0
All*	Total formula weight	28080.2

*Water molecules are not included.