4TLS
Crystal Structure of Human Transthyretin Glu92Pro Mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transthyretin | polymer | 125 | 13887.6 | 2 | UniProt (P02766) Pfam (PF00576) | Homo sapiens (Human) | ATTR,Prealbumin,TBPA |
| 2 | C, E (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 127 (UniProt: P02766)
| PDB | External Database | Details |
|---|---|---|
| Pro 92 | Glu 112 | engineered mutation |
| His 128 | - | expression tag |
| His 129 | - | expression tag |
| His 130 | - | expression tag |
| His 131 | - | expression tag |
| His 132 | - | expression tag |
| His 133 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27775.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 305.0 | |
| All* | Total formula weight | 28080.2 |
