4S15
Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Nuclear receptor ROR-alpha | polymer | 256 | 29845.5 | 2 | UniProt (P35398) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor RZR-alpha, Nuclear receptor subfamily 1 group F member 1, RAR-related orphan receptor A, Retinoid-related orphan receptor-alpha |
| 2 | B, D (C, D) | Nuclear receptor-interacting protein 1 | polymer | 12 | 1380.6 | 2 | UniProt (P48552) | Homo sapiens | Nuclear factor RIP140, Receptor-interacting protein 140 |
| 3 | E, G (A, B) | (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid | non-polymer | 442.7 | 2 | Chemie (4D8) PubChem (22298938) PubChem (25202088) PubChem (23724596) PubChem (53477909) PubChem (56927973) PubChem (42608395) PubChem (59782622) PubChem (59859270) PubChem (68544796) PubChem (71045961) PubChem (71051774) PubChem (656453) PubChem (129847581) PubChem (131769850) PubChem (165361783) PubChem (176183053) | |||
| 4 | F, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 5 | I, J, K, L (A, C, B, D) | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
A, B: 269 - 523 (UniProt: P35398)
| PDB | External Database | Details |
|---|---|---|
| Gly 268 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62452.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1069.5 | |
| All* | Total formula weight | 63521.8 |
