4S15
Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nuclear receptor ROR-alpha | polymer | 256 | 29845.5 | 2 | UniProt (P35398) Pfam (PF00104) In PDB | Homo sapiens (human) | Nuclear receptor RZR-alpha, Nuclear receptor subfamily 1 group F member 1, RAR-related orphan receptor A, Retinoid-related orphan receptor-alpha |
| 2 | C, D | Nuclear receptor-interacting protein 1 | polymer | 12 | 1380.6 | 2 | UniProt (P48552) In PDB | Homo sapiens | Nuclear factor RIP140, Receptor-interacting protein 140 |
| 3 | A, B | (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid | non-polymer | 442.7 | 2 | Chemie (4D8) | |||
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
A, B: 269 - 523 (UniProt: P35398)
| PDB | External Database | Details |
|---|---|---|
| Gly 268 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62452.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1069.5 | |
| All* | Total formula weight | 63521.8 |
