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4S15

Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 4D8 A 601
ChainResidue
AGLN289
AHOH757
AHOH764
ATYR290
AILE327
AALA330
AMET368
AVAL379
ATYR380
AVAL403
AGOL602

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 602
ChainResidue
ACYS288
AGLN289
ATYR290
AARG367
AARG370
A4D8601
AHOH706

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 4D8 B 601
ChainResidue
BGLN289
BTYR290
BTRP320
BILE327
BALA330
BMET368
BVAL379
BTYR380
BLEU394
BPHE399
BVAL403
BGOL602
BHOH751

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 602
ChainResidue
BCYS288
BGLN289
BTYR290
BARG367
BARG370
B4D8601

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS507
DLYS507

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PDB entries from 2024-11-06

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