4RXH

Crystal Structure of Importin-alpha from Neurospora crassa complexed with SV40NLS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Importin subunit alpha	polymer	495	53602.6	1	UniProt (Q9C2K9) Pfam (PF01749) Pfam (PF16186) Pfam (PF00514)	Neurospora crassa
2	B, C (A, C)	Large T antigen	polymer	8	985.3	2	UniProt (P03070)	Simian virus 40	LT, LT-AG
3	D, E, F (B, A, C)	water	water		18.0	349	Chemie (HOH)

Sequence modifications

B: 75 - 548 (UniProt: Q9C2K9)

PDB	External Database	Details
Met 54	-	expression tag
Gly 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
His 58	-	expression tag
His 59	-	expression tag
His 60	-	expression tag
His 61	-	expression tag
His 62	-	expression tag
His 63	-	expression tag
Ser 64	-	expression tag
Ser 65	-	expression tag
Gly 66	-	expression tag
Leu 67	-	expression tag
Val 68	-	expression tag
Pro 69	-	expression tag
Arg 70	-	expression tag
Gly 71	-	expression tag
Ser 72	-	expression tag
His 73	-	expression tag
Met 74	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55573.2
All*	Total formula weight	55573.2

*Water molecules are not included.