4RWS
Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | C-X-C chemokine receptor type 4/Endolysin chimeric protein | polymer | 498 | 56602.5 | 1 | UniProt (P61073) UniProt (P00720) Pfam (PF12109) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens | CXC-R4, CXCR-4, Stromal cell-derived factor 1 receptor, SDF-1 receptor, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, LCR1, FB22, NPYRL, HM89, Lysis protein, Muramidase, Endolysin |
2 | C | Viral macrophage inflammatory protein 2 | polymer | 80 | 9143.7 | 1 | UniProt (Q98157) Pfam (PF00048) In PDB | Human herpesvirus 8 strain GK18 (HHV-8) | Viral macrophage inflammatory protein II, vMIP-II, vMIP-1B |
Sequence modifications
A: 2 - 228 (UniProt: P61073)
A: 1002 - 1161 (UniProt: P00720)
A: 231 - 319 (UniProt: P61073)
C: 1 - 71 (UniProt: Q98157)
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
Trp 125 | Leu 125 | engineered mutation |
Cys 187 | Asp 187 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Thr 1054 | Cys 1054 | engineered mutation |
Ala 1097 | Cys 1097 | engineered mutation |
Ser 1162 | - | linker |
Gly 1163 | - | linker |
Ser 1164 | - | linker |
PDB | External Database | Details |
---|---|---|
Pro 240 | Thr 240 | engineered mutation |
Gly 320 | - | expression tag |
Arg 321 | - | expression tag |
Pro 322 | - | expression tag |
Leu 323 | - | expression tag |
Glu 324 | - | expression tag |
Val 325 | - | expression tag |
Leu 326 | - | expression tag |
Phe 327 | - | expression tag |
Gln 328 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 5 | Trp 28 | engineered mutation |
Tyr 72 | - | expression tag |
Pro 73 | - | expression tag |
Tyr 74 | - | expression tag |
Asp 75 | - | expression tag |
Val 76 | - | expression tag |
Pro 77 | - | expression tag |
Asp 78 | - | expression tag |
Tyr 79 | - | expression tag |
Ala 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65746.2 | |
All* | Total formula weight | 65746.2 |