4RWS
Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0019955 | molecular_function | cytokine binding |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
| C | 0005125 | molecular_function | cytokine activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006955 | biological_process | immune response |
| C | 0007165 | biological_process | signal transduction |
| C | 0008009 | molecular_function | chemokine activity |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0045236 | molecular_function | CXCR chemokine receptor binding |
| C | 0048245 | biological_process | eosinophil chemotaxis |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVwILAFISLDRYLaI |
| Chain | Residue | Details |
| A | SER122-ILE138 |
| site_id | PS00472 |
| Number of Residues | 42 |
| Details | SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLgyqkrp..LpqvlLssWyptsql..Cskp.GVIFltkrgrqv.CA |
| Chain | Residue | Details |
| C | CYS11-ALA52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | ILE39-MET63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | GLY64-ARG77 | |
| A | SER131-LYS154 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | LEU78-VAL99 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | ALA100-LYS110 | |
| A | ALA175-TRP195 | |
| A | ASP262-LYS282 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | ALA111-ILE130 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | VAL155-PHE174 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | VAL196-LEU216 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | VAL242-ILE261 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:20929726 |
| Chain | Residue | Details |
| A | TRP283-TYR302 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Chemokine binding |
| Chain | Residue | Details |
| A | ASP171 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Chemokine binding => ECO:0000269|PubMed:20929726, ECO:0000305|PubMed:10825158 |
| Chain | Residue | Details |
| A | GLU288 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Sulfotyrosine; partial => ECO:0000269|PubMed:18834145 |
| Chain | Residue | Details |
| A | TYR7 | |
| A | TYR12 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:12034737, ECO:0000269|PubMed:16725153, ECO:0000269|PubMed:18834145 |
| Chain | Residue | Details |
| A | TYR21 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER319 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10756055 |
| Chain | Residue | Details |
| A | ASN11 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:12034737 |
| Chain | Residue | Details |
| A | SER18 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN176 |
Catalytic Information from CSA
