4RWI

Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Fibroblast growth factor receptor 1	polymer	317	36258.7	2	UniProt (P11362) Pfam (PF07714) In PDB	Homo sapiens (human)	FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr
2		water	water		18.0	82	Chemie (HOH)

Sequence modifications

A, B: 458 - 765 (UniProt: P11362)

PDB	External Database	Details
Met 449	-	expression tag
Gly 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
Met 457	-	expression tag
Ala 488	Cys 488	engineered mutation
Met 561	Val 561	engineered mutation
Ser 584	Cys 584	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72517.3
All*	Total formula weight	72517.3

*Water molecules are not included.