4RTW
Crystal structure of the c-Src-SH3 domain E93V/Q128R mutant in complex with the high affinity peptide APP12
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Proto-oncogene tyrosine-protein kinase Src | polymer | 61 | 6904.6 | 2 | UniProt (P00523) Pfam (PF00018) In PDB | Gallus gallus (bantam chickens) | Proto-oncogene c-Src, pp60c-src, p60-Src |
2 | B, D, E | APP12 peptide | polymer | 13 | 1412.7 | 3 | |||
3 | A, C, D, E | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
4 | C | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, C: 85 - 141 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 81 | - | expression tag |
Ser 82 | - | expression tag |
His 83 | - | expression tag |
Met 84 | - | expression tag |
Val 93 | Glu 93 | engineered mutation |
Arg 128 | Gln 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 18047.3 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 476.3 | |
All* | Total formula weight | 18523.6 |