4RSY
Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leukotriene A-4 hydrolase | polymer | 631 | 71535.3 | 1 | UniProt (P09960) Pfam (PF17900) Pfam (PF01433) Pfam (PF09127) | Homo sapiens (human) | LTA-4 hydrolase, Leukotriene A(4) hydrolase |
| 2 | B (A) | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | non-polymer | 307.4 | 1 | Chemie (B3N) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | YTTERBIUM (III) ION | non-polymer | 173.0 | 1 | Chemie (YB) | |||
| 5 | E (A) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 6 | F (A) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 7 | G (A) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A: 0 - 610 (UniProt: P09960)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Val -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Arg -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 71535.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 675.0 | |
| All* | Total formula weight | 72210.3 |
