4RS1
Crystal structure of receptor-cytokine complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | polymer | 281 | 32873.0 | 1 | UniProt (P15509) Pfam (PF18611) Pfam (PF09240) | Homo sapiens (human) | GM-CSF-R-alpha, GMCSFR-alpha, GMR-alpha, CDw116 |
| 2 | B (A) | Granulocyte-macrophage colony-stimulating factor | polymer | 112 | 12870.8 | 1 | UniProt (P04141) Pfam (PF01109) | Homo sapiens (human) | GM-CSF, Colony-stimulating factor, CSF, Molgramostin, Sargramostim |
| 3 | C, D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | E (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | F, G (B, A) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
B: 16 - 296 (UniProt: P15509)
| PDB | External Database | Details |
|---|---|---|
| Gln 27 | Asn 46 | engineered mutation |
| Gln 35 | Asn 54 | engineered mutation |
| Gln 80 | Asn 99 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45743.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 534.5 | |
| All* | Total formula weight | 46278.3 |
