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4RMH

Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
NAD-dependent protein deacetylase sirtuin-2polymer30434416.71UniProt (Q8IXJ6)
Pfam (PF02146)
Homo sapiens (human)Regulatory protein SIR2 homolog 2, SIR2-like protein 2
2B
(B)
Ac-Lys-H3 peptidepolymer7728.81
3C
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
4D
(A)
2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamidenon-polymer420.61Chemie (3TE)
5E, F
(A, B)
waterwater18.0243Chemie (HOH)
Sequence modifications
A: 56 - 356 (UniProt: Q8IXJ6)
PDBExternal DatabaseDetails
Gly 53-expression tag
His 54-expression tag
Met 55-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight35145.5
Non-Polymers*Number of molecules2
Total formula weight486.0
All*Total formula weight35631.5
*Water molecules are not included.

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PDB entries from 2025-07-30

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