4RMH
Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 3TE A 402 |
| Chain | Residue |
| A | ALA135 |
| A | TYR139 |
| A | PRO140 |
| A | PHE143 |
| A | PHE190 |
| A | ILE232 |
| A | VAL233 |
| A | PHE234 |
| A | PHE96 |
| A | TYR104 |
| A | ILE118 |
| A | PHE119 |
| A | PHE131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
| Chain | Residue | Details |
| A | HIS187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25672491, ECO:0007744|PDB:4RMG |
| Chain | Residue | Details |
| A | ALA85 | |
| A | ASP95 | |
| A | GLN167 | |
| A | THR262 | |
| A | ASN286 | |
| A | CYS324 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:11427894, ECO:0000269|PubMed:23454361, ECO:0000269|PubMed:24389023, ECO:0000269|PubMed:25672491, ECO:0000269|PubMed:25704306, ECO:0007744|PDB:4R8M |
| Chain | Residue | Details |
| A | CYS195 | |
| A | CYS200 | |
| A | CYS221 | |
| A | CYS224 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5RJQ4 |
| Chain | Residue | Details |
| A | SER100 | |
| A | SER207 |
