4RI5

Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein phosphatase non-receptor type 3	polymer	306	34961.8	2	UniProt (P26045) Pfam (PF00102)	Homo sapiens (human)
2	C, E (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3	D, F (A, B)	oxido(dioxo)vanadium	non-polymer		98.9	2	Chemie (VN4)
4	G, H (A, B)	water	water		18.0	757	Chemie (HOH)

Sequence modifications

A, B: 628 - 909 (UniProt: P26045)

PDB	External Database	Details
Met -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Leu -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag
Glu 811	Asp 811	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69923.5
Non-Polymers*	Number of molecules	4
	Total formula weight	382.1
All*	Total formula weight	70305.6

*Water molecules are not included.