4QT2

Crystal Structure of the FK506-Binding Domain of Plasmodium Falciparum FKBP35 in complex with Rapamycin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	FK506-binding protein (FKBP)-type peptidyl-propyl isomerase	polymer	131	14828.7	1	UniProt (Q8I4V8) Pfam (PF00254)	Plasmodium falciparum 3D7
2	B (A)	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
3	C (A)	RAPAMYCIN IMMUNOSUPPRESSANT DRUG	non-polymer		914.2	1	Chemie (RAP) PubChem (21944094) PubChem (22524702) PubChem (22524747) PubChem (22525359) PubChem (176856347) PubChem (23351774) PubChem (23375411) PubChem (23376986) PubChem (23748515) PubChem (24870962) PubChem (24871327) PubChem (25200053) PubChem (25200063) PubChem (44120108) PubChem (16760052) PubChem (16760631) PubChem (17753749) PubChem (44476572) PubChem (44634693) PubChem (21176130) PubChem (21549991) PubChem (21863017) PubChem (22524575) PubChem (22525016) PubChem (22771180) PubChem (22829016) PubChem (23351773) PubChem (23375412) PubChem (23376988) PubChem (24150662) PubChem (24867259) PubChem (24871317) PubChem (25200284) PubChem (25200075) PubChem (25200308) PubChem (25266201) PubChem (54600319) PubChem (57579211) PubChem (57831856) PubChem (44295234) PubChem (58597069) PubChem (58597081) PubChem (58651220) PubChem (58651224) PubChem (58682959) PubChem (58725682) PubChem (58725688) PubChem (58731856) PubChem (58757256) PubChem (58818830) PubChem (58942911) PubChem (59079213) PubChem (59116632) PubChem (59262957) PubChem (44634703) PubChem (59716030) PubChem (59746150) PubChem (59761584) PubChem (59798735) PubChem (46835353) PubChem (59976377) PubChem (49652385) PubChem (70789198) PubChem (71296106) PubChem (53298413) PubChem (53627520) PubChem (478951) PubChem (73265225) PubChem (73438908) PubChem (145684635) PubChem (57312764) PubChem (57549339) PubChem (57747481) PubChem (57654444) PubChem (73896879) PubChem (57542109) PubChem (57831854) PubChem (58651218) PubChem (58731853) PubChem (58863407) PubChem (58681233) PubChem (58651217) PubChem (58682966) PubChem (58725690) PubChem (59032409) PubChem (59111212) PubChem (59079212) PubChem (59189008) PubChem (59584560) PubChem (59873116) PubChem (59741796) PubChem (59514927) PubChem (59695672) PubChem (59762850) PubChem (59716029) PubChem (59746146) PubChem (59798734) PubChem (59836921) PubChem (59762848) PubChem (59939263) PubChem (59843436) PubChem (60084327) PubChem (59965662) PubChem (59921726) PubChem (59972802) PubChem (59982608) PubChem (60003176) PubChem (60148419) PubChem (60146796) PubChem (86583604) PubChem (60150249) PubChem (88543353) PubChem (88877093) PubChem (88877541) PubChem (88982079) PubChem (143131348) PubChem (176481738) PubChem (89172501) PubChem (89222646) PubChem (89229297) PubChem (89288626) PubChem (176797660) PubChem (176878509) PubChem (177257072) PubChem (177410779) PubChem (5040) PubChem (65448) PubChem (90660428) PubChem (90660646) PubChem (313006) PubChem (71308609) PubChem (71463321) PubChem (73438890) PubChem (73707374) PubChem (73952167) PubChem (87199396) PubChem (87413824) PubChem (88877157) PubChem (88876970) PubChem (88938482) PubChem (88934904) PubChem (89164572) PubChem (89173639) PubChem (89263866) PubChem (89193790) PubChem (89203820) PubChem (89203981) PubChem (89382243) PubChem (89651883) PubChem (89691897) PubChem (91157894) PubChem (90830213) PubChem (90954095) PubChem (91059082) PubChem (91312280) PubChem (91407558) PubChem (5358081) PubChem (5284616) PubChem (98042555) PubChem (99726904) PubChem (99726905) PubChem (99719687) PubChem (99726902) PubChem (99719685) PubChem (101058122) PubChem (5374464) PubChem (5460439) PubChem (5497196) PubChem (5924240) PubChem (118028380) PubChem (6610346) PubChem (6711160) PubChem (6713081) PubChem (123319649) PubChem (123375319) PubChem (123284252) PubChem (123579029) PubChem (123745020) PubChem (123961550) PubChem (124202144) PubChem (124202163) PubChem (9833581) PubChem (9854379) PubChem (124923869) PubChem (125182984) PubChem (9962926) PubChem (126706235) PubChem (6436030) PubChem (129018336) PubChem (10213190) PubChem (129396805) PubChem (131674889) PubChem (131668123) PubChem (132342626) PubChem (6610270) PubChem (133550001) PubChem (99719686) PubChem (99726903) PubChem (118701644) PubChem (118968446) PubChem (134812764) PubChem (11959112) PubChem (9854380) PubChem (136197703) PubChem (137146980) PubChem (137126527) PubChem (9962928) PubChem (137154395) PubChem (137154392) PubChem (137154394) PubChem (137159082) PubChem (137303712) PubChem (137321130) PubChem (123132513) PubChem (123685353) PubChem (137513797) PubChem (123966602) PubChem (124202326) PubChem (140457701) PubChem (140509544) PubChem (140495012) PubChem (141827210) PubChem (11949238) PubChem (13003162) PubChem (146165671) PubChem (149030593) PubChem (149030595) PubChem (154539809) PubChem (155923785) PubChem (154575194) PubChem (124923870) PubChem (124923871) PubChem (124923872) PubChem (157691735) PubChem (158004723) PubChem (158004725) PubChem (158667905) PubChem (158667900) PubChem (159512395) PubChem (160401076) PubChem (160401082) PubChem (160401068) PubChem (160843420) PubChem (160401063) PubChem (160401067) PubChem (160401073) PubChem (160843418) PubChem (160401077) PubChem (160559912) PubChem (161552714) PubChem (162393098) PubChem (162702738) PubChem (162907223) PubChem (162907225) PubChem (162907221) PubChem (163193694) PubChem (163359781) PubChem (163895655) PubChem (163895656) PubChem (163978502) PubChem (166639084) PubChem (167403487) PubChem (168267583) PubChem (168314647) PubChem (168843998) PubChem (168810792) PubChem (169766759) PubChem (170922362) PubChem (170996834) PubChem (171042528) PubChem (171329380) PubChem (171360948) PubChem (171607084) PubChem (171991699) PubChem (129010340) PubChem (173549023) PubChem (173303291) PubChem (173381240) PubChem (173209376) PubChem (173484164) PubChem (173477043) PubChem (173523625) PubChem (173644621) PubChem (173628231) PubChem (173732063) PubChem (173790728) PubChem (174051096) PubChem (174079707) PubChem (174086051) PubChem (175963732) PubChem (129150908) PubChem (134129699) PubChem (134572840) PubChem (134760597) PubChem (137146981) PubChem (137146982) PubChem (137154393) PubChem (137244727) PubChem (137795242) PubChem (138106895) PubChem (138404388) PubChem (140456940) PubChem (140495013) PubChem (140504269) PubChem (149030591) PubChem (149030592) PubChem (149030594) PubChem (153274811) PubChem (153484733) PubChem (154547638) PubChem (157502692) PubChem (157507229) PubChem (160401064) PubChem (160401065) PubChem (160401066) PubChem (160401069) PubChem (160401070) PubChem (160401071) PubChem (160401072) PubChem (160401074) PubChem (160401075) PubChem (160401078) PubChem (160401079) PubChem (160401080) PubChem (160401081) PubChem (161095401) PubChem (161095402) PubChem (161418798) PubChem (162907222) PubChem (162907224) PubChem (163895657) PubChem (166604446) PubChem (168311769) PubChem (169962415) PubChem (171125838) PubChem (171159772) PubChem (171703108) PubChem (171761843) PubChem (172017404) PubChem (172018138) PubChem (172503251) PubChem (173075346) PubChem (173296700) PubChem (173303290) PubChem (173303292) PubChem (173303664) PubChem (173382757) PubChem (173481203) PubChem (173493552) PubChem (173512554) PubChem (173614191) PubChem (173682385) PubChem (175673538) PubChem (175737102) PubChem (176418841)
4	D (A)	water	water		18.0	99	Chemie (HOH)

Sequence modifications

A: 7 - 127 (UniProt: Q8I4V8)

PDB	External Database	Details
Leu 128	-	expression tag
Glu 129	-	expression tag
Thr 130	-	expression tag
Ser 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	14828.7
Non-Polymers*	Number of molecules	2
	Total formula weight	983.3
All*	Total formula weight	15812.0

*Water molecules are not included.