4QOZ

Crystal structure of the histone mRNA stem-loop, stem-loop binding protein (phosphorylated), and 3'hExo ternary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	histone mRNA stem-loop	polymer	26	8223.0	2
2	B, E	3'-5' exoribonuclease 1	polymer	303	35346.7	2	UniProt (Q8IV48) Pfam (PF02037) Pfam (PF00929) In PDB	Homo sapiens (human)	3'-5' exonuclease ERI1, Eri-1 homolog, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, Protein 3'hExo, HEXO
3	C	Histone RNA hairpin-binding protein	polymer	120	14152.8	1	UniProt (Q14493) Pfam (PF15247) In PDB	Homo sapiens (human)	Histone stem-loop-binding protein
4		water	water		18.0	297	Chemie (HOH)

Sequence modifications

B, E: 55 - 349 (UniProt: Q8IV48)

PDB	External Database	Details
Leu 350	-	EXPRESSION TAG
Glu 351	-	EXPRESSION TAG
His 352	-	EXPRESSION TAG
His 353	-	EXPRESSION TAG
His 354	-	EXPRESSION TAG
His 355	-	EXPRESSION TAG
His 356	-	EXPRESSION TAG
His 357	-	EXPRESSION TAG

C: 125 - 223 (UniProt: Q14493)

PDB	External Database	Details
Met 104	-	EXPRESSION TAG
Gly 105	-	EXPRESSION TAG
Ser 106	-	EXPRESSION TAG
Ser 107	-	EXPRESSION TAG
His 108	-	EXPRESSION TAG
His 109	-	EXPRESSION TAG
His 110	-	EXPRESSION TAG
His 111	-	EXPRESSION TAG
His 112	-	EXPRESSION TAG
His 113	-	EXPRESSION TAG
Ser 114	-	EXPRESSION TAG
Ser 115	-	EXPRESSION TAG
Gly 116	-	EXPRESSION TAG
Leu 117	-	EXPRESSION TAG
Val 118	-	EXPRESSION TAG
Pro 119	-	EXPRESSION TAG
Arg 120	-	EXPRESSION TAG
Gly 121	-	EXPRESSION TAG
Ser 122	-	EXPRESSION TAG
His 123	-	EXPRESSION TAG
Met 124	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	101292.1
All*	Total formula weight	101292.1

*Water molecules are not included.