4QOC
crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, C, E, G, I...) | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11156.1 | 6 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | G, H, I, J, K... (A, C, E, G, I...) | {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-(pyrrolidin-1-ylsulfonyl)ethyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid | non-polymer | 593.6 | 6 | Chemie (35T) | |||
| 3 | M, N, O, P, Q... (A, C, E, G, I...) | water | water | 18.0 | 603 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 66936.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3561.4 | |
| All* | Total formula weight | 70497.7 |
