4QOC
crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0051726 | biological_process | regulation of cell cycle |
C | 0005634 | cellular_component | nucleus |
C | 0043066 | biological_process | negative regulation of apoptotic process |
C | 0051726 | biological_process | regulation of cell cycle |
E | 0005634 | cellular_component | nucleus |
E | 0043066 | biological_process | negative regulation of apoptotic process |
E | 0051726 | biological_process | regulation of cell cycle |
G | 0005634 | cellular_component | nucleus |
G | 0043066 | biological_process | negative regulation of apoptotic process |
G | 0051726 | biological_process | regulation of cell cycle |
I | 0005634 | cellular_component | nucleus |
I | 0043066 | biological_process | negative regulation of apoptotic process |
I | 0051726 | biological_process | regulation of cell cycle |
K | 0005634 | cellular_component | nucleus |
K | 0043066 | biological_process | negative regulation of apoptotic process |
K | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 35T A 201 |
Chain | Residue |
A | LEU54 |
A | TYR100 |
A | HOH306 |
A | HOH324 |
A | HOH337 |
A | HOH344 |
A | HOH357 |
K | GLN18 |
K | ARG97 |
K | LYS98 |
A | GLY58 |
A | ILE61 |
A | MET62 |
A | TYR67 |
A | VAL93 |
A | LYS94 |
A | HIS96 |
A | ILE99 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 35T C 201 |
Chain | Residue |
C | LEU54 |
C | GLY58 |
C | ILE61 |
C | TYR67 |
C | VAL93 |
C | LYS94 |
C | HIS96 |
C | ILE99 |
C | TYR100 |
C | HOH314 |
C | HOH324 |
C | HOH391 |
G | ARG97 |
G | LYS98 |
site_id | AC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 35T E 201 |
Chain | Residue |
C | ARG97 |
C | LYS98 |
C | THR101 |
E | LEU54 |
E | LEU57 |
E | GLY58 |
E | GLN59 |
E | ILE61 |
E | TYR67 |
E | VAL93 |
E | LYS94 |
E | HIS96 |
E | ILE99 |
E | TYR100 |
E | HOH311 |
E | HOH342 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 35T G 201 |
Chain | Residue |
G | GLY58 |
G | ILE61 |
G | TYR67 |
G | VAL93 |
G | LYS94 |
G | HIS96 |
G | ILE99 |
G | HOH312 |
G | HOH379 |
G | HOH387 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 35T I 201 |
Chain | Residue |
A | ARG97 |
A | LYS98 |
A | THR101 |
I | LEU54 |
I | GLY58 |
I | ILE61 |
I | TYR67 |
I | VAL93 |
I | LYS94 |
I | HIS96 |
I | ILE99 |
I | HOH302 |
I | HOH373 |
site_id | AC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 35T K 201 |
Chain | Residue |
K | LEU54 |
K | PHE55 |
K | GLY58 |
K | GLN59 |
K | ILE61 |
K | PHE86 |
K | VAL93 |
K | LYS94 |
K | HIS96 |
K | ILE99 |
K | TYR100 |
K | HOH332 |
K | HOH363 |