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4QOC

crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
C0005634cellular_componentnucleus
C0043066biological_processnegative regulation of apoptotic process
C0051726biological_processregulation of cell cycle
E0005634cellular_componentnucleus
E0043066biological_processnegative regulation of apoptotic process
E0051726biological_processregulation of cell cycle
G0005634cellular_componentnucleus
G0043066biological_processnegative regulation of apoptotic process
G0051726biological_processregulation of cell cycle
I0005634cellular_componentnucleus
I0043066biological_processnegative regulation of apoptotic process
I0051726biological_processregulation of cell cycle
K0005634cellular_componentnucleus
K0043066biological_processnegative regulation of apoptotic process
K0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 35T A 201
ChainResidue
ALEU54
ATYR100
AHOH306
AHOH324
AHOH337
AHOH344
AHOH357
KGLN18
KARG97
KLYS98
AGLY58
AILE61
AMET62
ATYR67
AVAL93
ALYS94
AHIS96
AILE99

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 35T C 201
ChainResidue
CLEU54
CGLY58
CILE61
CTYR67
CVAL93
CLYS94
CHIS96
CILE99
CTYR100
CHOH314
CHOH324
CHOH391
GARG97
GLYS98

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 35T E 201
ChainResidue
CARG97
CLYS98
CTHR101
ELEU54
ELEU57
EGLY58
EGLN59
EILE61
ETYR67
EVAL93
ELYS94
EHIS96
EILE99
ETYR100
EHOH311
EHOH342

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 35T G 201
ChainResidue
GGLY58
GILE61
GTYR67
GVAL93
GLYS94
GHIS96
GILE99
GHOH312
GHOH379
GHOH387

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 35T I 201
ChainResidue
AARG97
ALYS98
ATHR101
ILEU54
IGLY58
IILE61
ITYR67
IVAL93
ILYS94
IHIS96
IILE99
IHOH302
IHOH373

site_idAC6
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 35T K 201
ChainResidue
KLEU54
KPHE55
KGLY58
KGLN59
KILE61
KPHE86
KVAL93
KLYS94
KHIS96
KILE99
KTYR100
KHOH332
KHOH363

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PDB entries from 2024-04-24

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