4QJR
Crystal structure of human nuclear receptor sf-1 (nr5a1) bound to its hormone pip3 at 2.4 a resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Steroidogenic factor 1 | polymer | 245 | 27903.4 | 1 | UniProt (Q13285) Pfam (PF00104) | Homo sapiens (human) | SF-1, STF-1, Adrenal 4-binding protein, Fushi tarazu factor homolog 1, Nuclear receptor subfamily 5 group A member 1, Steroid hormone receptor Ad4BP |
| 2 | B (B) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 14 | 1523.9 | 1 | UniProt (Q9UBK2) | Homo sapiens | PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, Ligand effect modulator 6 |
| 3 | C (A) | (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate | non-polymer | 1051.0 | 1 | Chemie (PIZ) | |||
| 4 | D, E (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | F (A) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 218 - 461 (UniProt: Q13285)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 247 | Cys 247 | engineered mutation |
| Ser 412 | Cys 412 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29427.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1169.1 | |
| All* | Total formula weight | 30596.3 |
