4QJR

Crystal structure of human nuclear receptor sf-1 (nr5a1) bound to its hormone pip3 at 2.4 a resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE PIZ A 501

Chain	Residue
A	PHE262
A	TYR436
A	LYS440
A	HOH612
A	HOH613
A	HOH619
A	HOH654
A	HOH691
A	HOH694
A	HOH695
A	HOH696
A	LEU265
A	LEU306
A	VAL336
A	GLN339
A	ALA340
A	GLY341
A	LEU344
A	ALA351

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ACT A 502

Chain	Residue
A	TYR438
A	TYR438
A	LEU456
A	LEU456
A	GLN457
A	GLN457
A	HOH690
A	HOH690
A	HOH708
A	HOH708

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 503

Chain	Residue
A	THR272
A	SER275
A	ASP309
A	HOH711

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	237
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	231
Details	Region: {"description":"Important for dimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15897460","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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