4QJ3

Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(q) subunit alpha	polymer	379	44711.6	1	UniProt (P21279) Pfam (PF00503) In PDB	Mus musculus (mouse)	Guanine nucleotide-binding protein alpha-q
2	B	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	polymer	793	90294.2	1	UniProt (Q01970) Pfam (PF17787) Pfam (PF22631) Pfam (PF00388) Pfam (PF00387) Pfam (PF00168) In PDB	Homo sapiens (human)	Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3
3	A	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
4	A	TETRAFLUOROALUMINATE ION	non-polymer		103.0	1	Chemie (ALF)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	B	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
7		water	water		18.0	28	Chemie (HOH)

Sequence modifications

A: 7 - 359 (UniProt: P21279)

PDB	External Database	Details
Met -19	-	expression tag
Ser -18	-	expression tag
Tyr -17	-	expression tag
Tyr -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Asp -9	-	expression tag
Tyr -8	-	expression tag
Asp -7	-	expression tag
Ile -6	-	expression tag
Pro -5	-	expression tag
Thr -4	-	expression tag
Thr -3	-	expression tag
Glu -2	-	expression tag
Asn -1	-	expression tag
Leu 0	-	expression tag
Tyr 1	-	expression tag
Phe 2	-	expression tag
Gln 3	-	expression tag
Gly 4	-	expression tag
Ala 5	-	expression tag
Ala 6	-	expression tag

B: 10 - 470 (UniProt: Q01970)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Gly 8	-	expression tag
Thr 9	-	expression tag

B: 570 - 891 (UniProt: Q01970)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	135005.7
Non-Polymers*	Number of molecules	4
	Total formula weight	610.6
All*	Total formula weight	135616.3

*Water molecules are not included.