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4QA1

Crystal structure of A188T HDAC8 in complex with M344

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Histone deacetylase 8polymer38943262.04UniProt (Q9BY41)
Pfam (PF00850)
Homo sapiens (human)HD8
2E, F, J, K, P...
(A, B, C, D)
POTASSIUM IONnon-polymer39.18Chemie (K)
3G, L, R, W
(A, B, C, D)
ZINC IONnon-polymer65.44Chemie (ZN)
4H, M, S, X
(A, B, C, D)
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamidenon-polymer307.44Chemie (B3N)
5I, N, O, T
(A, B, C)
GLYCEROLnon-polymer92.14Chemie (GOL)
6AA, BA, Y, Z
(C, D, A, B)
waterwater18.01221Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 377 (UniProt: Q9BY41)
PDBExternal DatabaseDetails
Thr 188Ala 188engineered mutation
Ile 378-expression tag
Glu 379-expression tag
Gly 380-expression tag
Arg 381-expression tag
Gly 382-expression tag
Ser 383-expression tag
His 384-expression tag
His 385-expression tag
His 386-expression tag
His 387-expression tag
His 388-expression tag
His 389-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight173048.1
Non-Polymers*Number of molecules20
Total formula weight2172.3
All*Total formula weight175220.4
*Water molecules are not included.

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PDB entries from 2025-07-02

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