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4QA1

Crystal structure of A188T HDAC8 in complex with M344

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000228cellular_componentnuclear chromosome
A0004407molecular_functionhistone deacetylase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0006325biological_processchromatin organization
A0007064biological_processmitotic sister chromatid cohesion
A0016787molecular_functionhydrolase activity
A0030544molecular_functionHsp70 protein binding
A0031397biological_processnegative regulation of protein ubiquitination
A0031647biological_processregulation of protein stability
A0032204biological_processregulation of telomere maintenance
A0033558molecular_functionprotein lysine deacetylase activity
A0040029biological_processepigenetic regulation of gene expression
A0046872molecular_functionmetal ion binding
A0051879molecular_functionHsp90 protein binding
A0140297molecular_functionDNA-binding transcription factor binding
A0160008molecular_functionprotein decrotonylase activity
A0160009molecular_functionhistone decrotonylase activity
B0000118cellular_componenthistone deacetylase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000228cellular_componentnuclear chromosome
B0004407molecular_functionhistone deacetylase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0006325biological_processchromatin organization
B0007064biological_processmitotic sister chromatid cohesion
B0016787molecular_functionhydrolase activity
B0030544molecular_functionHsp70 protein binding
B0031397biological_processnegative regulation of protein ubiquitination
B0031647biological_processregulation of protein stability
B0032204biological_processregulation of telomere maintenance
B0033558molecular_functionprotein lysine deacetylase activity
B0040029biological_processepigenetic regulation of gene expression
B0046872molecular_functionmetal ion binding
B0051879molecular_functionHsp90 protein binding
B0140297molecular_functionDNA-binding transcription factor binding
B0160008molecular_functionprotein decrotonylase activity
B0160009molecular_functionhistone decrotonylase activity
C0000118cellular_componenthistone deacetylase complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000228cellular_componentnuclear chromosome
C0004407molecular_functionhistone deacetylase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0006325biological_processchromatin organization
C0007064biological_processmitotic sister chromatid cohesion
C0016787molecular_functionhydrolase activity
C0030544molecular_functionHsp70 protein binding
C0031397biological_processnegative regulation of protein ubiquitination
C0031647biological_processregulation of protein stability
C0032204biological_processregulation of telomere maintenance
C0033558molecular_functionprotein lysine deacetylase activity
C0040029biological_processepigenetic regulation of gene expression
C0046872molecular_functionmetal ion binding
C0051879molecular_functionHsp90 protein binding
C0140297molecular_functionDNA-binding transcription factor binding
C0160008molecular_functionprotein decrotonylase activity
C0160009molecular_functionhistone decrotonylase activity
D0000118cellular_componenthistone deacetylase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000228cellular_componentnuclear chromosome
D0004407molecular_functionhistone deacetylase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0006325biological_processchromatin organization
D0007064biological_processmitotic sister chromatid cohesion
D0016787molecular_functionhydrolase activity
D0030544molecular_functionHsp70 protein binding
D0031397biological_processnegative regulation of protein ubiquitination
D0031647biological_processregulation of protein stability
D0032204biological_processregulation of telomere maintenance
D0033558molecular_functionprotein lysine deacetylase activity
D0040029biological_processepigenetic regulation of gene expression
D0046872molecular_functionmetal ion binding
D0051879molecular_functionHsp90 protein binding
D0140297molecular_functionDNA-binding transcription factor binding
D0160008molecular_functionprotein decrotonylase activity
D0160009molecular_functionhistone decrotonylase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A 401
ChainResidue
AASP176
AASP178
AHIS180
ASER199
ALEU200

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 402
ChainResidue
AHOH507
AHOH514
APHE189
ATHR192
AVAL195
ATYR225

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 403
ChainResidue
AASP178
AHIS180
AASP267
AB3N404

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE B3N A 404
ChainResidue
ATYR100
AASP101
AHIS142
AHIS143
AGLY151
APHE152
AASP178
AHIS180
AASP267
ATYR306
AZN403
AGOL405
AHOH675
BPHE152
BPRO273
BMET274
BTYR306

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 405
ChainResidue
ALYS33
APHE152
AB3N404
BLYS33

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K B 401
ChainResidue
BASP176
BASP178
BHIS180
BSER199
BLEU200

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K B 402
ChainResidue
BPHE189
BTHR192
BVAL195
BTYR225
BHOH501
BHOH504

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 403
ChainResidue
BASP178
BHIS180
BASP267
BB3N404

site_idAC9
Number of Residues17
DetailsBINDING SITE FOR RESIDUE B3N B 404
ChainResidue
ALYS33
APRO273
ATYR306
BTYR100
BHIS142
BHIS143
BGLY151
BPHE152
BASP178
BHIS180
BPHE208
BASP267
BTYR306
BZN403
BHOH512
BHOH696
BHOH783

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 405
ChainResidue
BALA68
BTHR69
BPHE70
BHIS71
BTHR72
BHOH576

site_idBC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 406
ChainResidue
AALA32
ALYS33
APRO103
BALA32
BLYS33
BHOH659
BHOH771
BHOH841

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K C 401
ChainResidue
CASP176
CASP178
CHIS180
CSER199
CLEU200

site_idBC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K C 402
ChainResidue
CPHE189
CTHR192
CVAL195
CTYR225
CHOH521
CHOH527

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 403
ChainResidue
CASP178
CHIS180
CASP267
CB3N404

site_idBC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE B3N C 404
ChainResidue
CHIS142
CHIS143
CGLY151
CPHE152
CASP178
CHIS180
CPHE208
CASP267
CTYR306
CZN403
CHOH658
DPHE152
DPRO273
DMET274
DTYR306
CTYR100
CASP101

site_idBC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL C 405
ChainResidue
CALA32
CLYS33
CPRO103
DALA32
DLYS33

site_idBC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K D 401
ChainResidue
DASP176
DASP178
DHIS180
DSER199
DLEU200

site_idBC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K D 402
ChainResidue
DPHE189
DTHR192
DVAL195
DTYR225
DHOH501
DHOH502

site_idCC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 403
ChainResidue
DASP178
DHIS180
DASP267
DB3N404

site_idCC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE B3N D 404
ChainResidue
CLYS33
CPHE152
CPRO273
CTYR306
DTYR100
DHIS142
DHIS143
DGLY151
DASP178
DHIS180
DPHE208
DASP267
DGLY304
DTYR306
DZN403
DHOH532
DHOH691

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000269|PubMed:19053282
ChainResidueDetails
AHIS143
BHIS143
CHIS143
DHIS143

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:19053282
ChainResidueDetails
AASP101
DASP101
DGLY151
DTYR306
AGLY151
ATYR306
BASP101
BGLY151
BTYR306
CASP101
CGLY151
CTYR306

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:17721440
ChainResidueDetails
AASP178
DASP178
DHIS180
DASP267
AHIS180
AASP267
BASP178
BHIS180
BASP267
CASP178
CHIS180
CASP267

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15242608
ChainResidueDetails
ASER39
BSER39
CSER39
DSER39

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PDB entries from 2024-07-31

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