4Q6G
Crystal Structure of the C-terminal domain of AcKRS-1 bound with N-acetyl-lysine and ADPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pyrrolysine--tRNA ligase | polymer | 267 | 30812.2 | 1 | UniProt (Q8PWY1) Pfam (PF01409) | Methanosarcina mazei | AcKRS-1, Pyrrolysine--tRNA(Pyl) ligase, Pyrrolysyl-tRNA synthetase, PylRS |
| 2 | B (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | I (A) | N(6)-ACETYLLYSINE | non-polymer | 188.2 | 1 | Chemie (ALY) | |||
| 5 | J (A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 188 - 454 (UniProt: Q8PWY1)
| PDB | External Database | Details |
|---|---|---|
| Val 301 | Leu 301 | engineered mutation |
| Ile 305 | Leu 305 | engineered mutation |
| Phe 306 | Tyr 306 | engineered mutation |
| Ala 309 | Leu 309 | engineered mutation |
| Phe 348 | Cys 348 | engineered mutation |
| Ser 382 | Met 382 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30812.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1066.8 | |
| All* | Total formula weight | 31879.1 |
