4Q3S

Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Arginase	polymer	385	42267.3	4	UniProt (Q6WVP6) Pfam (PF00491)	Schistosoma mansoni (Blood fluke)
2	E, F, K, L, Q... (A, B, C, D)	MANGANESE (II) ION	non-polymer		54.9	8	Chemie (MN)
3	G, M, S, X (A, B, C, D)	[(5R)-5-amino-5-carboxy-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-)	non-polymer		303.2	4	Chemie (X7A)
4	H, I, J, N, O... (A, B, C)	GLYCEROL	non-polymer		92.1	8	Chemie (GOL)
5	AA, BA, Y, Z (C, D, A, B)	water	water		18.0	849	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 364 (UniProt: Q6WVP6)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	169069.2
Non-Polymers*	Number of molecules	20
	Total formula weight	2389.0
All*	Total formula weight	171458.2

*Water molecules are not included.