4Q3S
Crystal structure of Schistosoma mansoni arginase in complex with inhibitor ABHPE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000050 | biological_process | urea cycle |
A | 0004053 | molecular_function | arginase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006525 | biological_process | arginine metabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
A | 0019547 | biological_process | arginine catabolic process to ornithine |
A | 0030145 | molecular_function | manganese ion binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0000050 | biological_process | urea cycle |
B | 0004053 | molecular_function | arginase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006525 | biological_process | arginine metabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
B | 0019547 | biological_process | arginine catabolic process to ornithine |
B | 0030145 | molecular_function | manganese ion binding |
B | 0046872 | molecular_function | metal ion binding |
C | 0000050 | biological_process | urea cycle |
C | 0004053 | molecular_function | arginase activity |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006525 | biological_process | arginine metabolic process |
C | 0016787 | molecular_function | hydrolase activity |
C | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
C | 0019547 | biological_process | arginine catabolic process to ornithine |
C | 0030145 | molecular_function | manganese ion binding |
C | 0046872 | molecular_function | metal ion binding |
D | 0000050 | biological_process | urea cycle |
D | 0004053 | molecular_function | arginase activity |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006525 | biological_process | arginine metabolic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
D | 0019547 | biological_process | arginine catabolic process to ornithine |
D | 0030145 | molecular_function | manganese ion binding |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 401 |
Chain | Residue |
A | HIS131 |
A | ASP154 |
A | ASP158 |
A | ASP262 |
A | MN402 |
A | X7A403 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 402 |
Chain | Residue |
A | ASP264 |
A | MN401 |
A | X7A403 |
A | ASP154 |
A | HIS156 |
A | ASP262 |
site_id | AC3 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE X7A A 403 |
Chain | Residue |
A | HIS131 |
A | ASP154 |
A | HIS156 |
A | ASP158 |
A | ASN160 |
A | SER167 |
A | HIS171 |
A | ASP211 |
A | ASP213 |
A | ASP262 |
A | ASP264 |
A | THR276 |
A | GLU307 |
A | MN401 |
A | MN402 |
A | HOH501 |
A | HOH502 |
A | HOH503 |
A | HOH504 |
A | HOH512 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 404 |
Chain | Residue |
A | ASP79 |
A | PRO80 |
A | GLN81 |
A | LYS86 |
A | TRP87 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 405 |
Chain | Residue |
A | ASN32 |
A | GLU73 |
A | HOH721 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 406 |
Chain | Residue |
A | TYR227 |
A | ASP232 |
A | HOH613 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN B 401 |
Chain | Residue |
B | HIS131 |
B | ASP154 |
B | ASP158 |
B | ASP262 |
B | MN402 |
B | X7A403 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN B 402 |
Chain | Residue |
B | ASP154 |
B | HIS156 |
B | ASP262 |
B | ASP264 |
B | MN401 |
B | X7A403 |
site_id | AC9 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE X7A B 403 |
Chain | Residue |
B | HIS131 |
B | ASP154 |
B | HIS156 |
B | ASP158 |
B | ASN160 |
B | SER167 |
B | HIS171 |
B | ASP211 |
B | ASP213 |
B | ASP262 |
B | ASP264 |
B | THR276 |
B | GLU307 |
B | MN401 |
B | MN402 |
B | HOH501 |
B | HOH502 |
B | HOH506 |
B | HOH507 |
B | HOH549 |
B | HOH557 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 404 |
Chain | Residue |
B | ASP79 |
B | PRO80 |
B | GLN81 |
B | LYS86 |
B | TRP87 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 405 |
Chain | Residue |
B | ASN32 |
B | ILE38 |
B | GLU73 |
B | HOH540 |
site_id | BC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 406 |
Chain | Residue |
B | TYR227 |
B | ASP232 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN C 401 |
Chain | Residue |
C | HIS131 |
C | ASP154 |
C | ASP158 |
C | ASP262 |
C | MN402 |
C | X7A403 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN C 402 |
Chain | Residue |
C | ASP154 |
C | HIS156 |
C | ASP262 |
C | ASP264 |
C | MN401 |
C | X7A403 |
site_id | BC6 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE X7A C 403 |
Chain | Residue |
C | HIS131 |
C | ASP154 |
C | HIS156 |
C | ASP158 |
C | ASN160 |
C | SER167 |
C | HIS171 |
C | ASP211 |
C | ASP213 |
C | ASP262 |
C | ASP264 |
C | THR276 |
C | GLU307 |
C | MN401 |
C | MN402 |
C | HOH502 |
C | HOH503 |
C | HOH504 |
C | HOH531 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL C 404 |
Chain | Residue |
C | ASP79 |
C | PRO80 |
C | GLN81 |
C | LYS86 |
C | TRP87 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL C 405 |
Chain | Residue |
C | ASN32 |
C | ILE38 |
C | GLU73 |
C | HOH568 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN D 401 |
Chain | Residue |
D | HIS131 |
D | ASP154 |
D | ASP158 |
D | ASP262 |
D | MN402 |
D | X7A403 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN D 402 |
Chain | Residue |
D | ASP154 |
D | HIS156 |
D | ASP262 |
D | ASP264 |
D | MN401 |
D | X7A403 |
site_id | CC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE X7A D 403 |
Chain | Residue |
D | HIS131 |
D | ASP154 |
D | HIS156 |
D | ASP158 |
D | ASN160 |
D | SER167 |
D | HIS171 |
D | ASP211 |
D | ASP213 |
D | ASP262 |
D | ASP264 |
D | THR276 |
D | GLU307 |
D | MN401 |
D | MN402 |
D | HOH501 |
D | HOH508 |
D | HOH511 |
D | HOH522 |
Functional Information from PROSITE/UniProt
site_id | PS01053 |
Number of Residues | 22 |
Details | ARGINASE_1 Arginase family signature. SFDIDaldPlvaPStgtavpgG |
Chain | Residue | Details |
A | SER260-GLY281 |