4Q0D
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, methotrexate and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E, A, B, C, D | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 521 | 60262.5 | 5 | UniProt (Q5CGA3) In PDB | Cryptosporidium hominis | |
| 2 | E, A, B, C, D | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 5 | Chemie (NDP) | |||
| 3 | E, A, B, C, D | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 326.2 | 5 | Chemie (UFP) | |||
| 4 | E, A, B, C, D | N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid | non-polymer | 413.4 | 5 | Chemie (2XB) | |||
| 5 | E, A, B, C, D | METHOTREXATE | non-polymer | 454.4 | 5 | Chemie (MTX) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 301312.6 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 9697.1 | |
| All* | Total formula weight | 311009.7 |
